Helical nucleopeptides

Details Helical nucleopeptides Helical nucleopeptides

2007-02-27

2007-02-27

Riley, Jezia (Department: 1637)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C536S024300, C536S025300, C435S006120

Reexamination Certificate

active

10110017

ABSTRACT:
The present invention relates to peptide-based nucleic acid surrogates (PNAs) having a repeating structure of (AAB-aan)mand a particular secondary structure that can bind to particular single-stranded nucleic acid targets. Preferably the peptide-based nucleic acid surrogate has an alpha-helical secondary structure (αPNA). Also, the present invention relates to the method of forming peptide-based nucleic acid surrogates having a particular secondary structure. The nucleic acid surrogates may be utilized for therapeutic (antisense, antigene), diagnostic (genetic), and molecular switching (αPNA chips) applications.

REFERENCES:
patent: WO92/20702 (1992-11-01), None
Garner et al. Modular Nucleic Acid Surrogates. Solid Phase Synthesis of Helical peptide NUcleic Acids ( PNAs) Organic Letters Aug. 12, 1999, vol. 1, No. 3 pp. 403-405.
Scarfi et al. Biochemical and Biophysical Research Communications 236, 323-326 1997.

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