Hammerhead-like nucleic acid analogues and their synthesis

Details Hammerhead-like nucleic acid analogues and their synthesis Hammerhead-like nucleic acid analogues and their synthesis

1996-03-20

1998-06-23

Kight, John

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 2534, 536 243, 536 245, C07H 2100

Patent

active

057707154

ABSTRACT:
The present invention provides nucleic acid compounds which have a non-nucleic acid structure with ring skeleton to which two functional groups are bound with fixed state and are able to point to substantially the same direction, nucleic acid compounds which can form triple strands with third nucleotide chains, nucleic acid compounds which have improved permeability, and synthetic methods thereof.

REFERENCES:
Manoharan, "Designer Antisense Oligonucleotides: Conjugation Chemistry and Functionality Placement," Ch. 17 in Antisense Research and Applications, Crooke & LeBleu (eds.), CRC Press, Inc., Boca Raton, FL, 1993, 579 pages, only pp. 303-349 supplied.
Sugiyama et al., "Catalytic Activities of Hammerhead Ribozymes With a Triterpenoid Linker Instead of Stem/Loop II," FEBS Letters, 392(3), 215-219 (Sep. 2, 1996).
Hirao, et al., Most compact hairpin-turn structure exerted by a short DNA fragment, d(GCGAAGC) in solution: an extraordinarily stable structure resistant to nucleases and heat, Nucleic Acids Research, 22(4):576, 1994.
Hirao, et al., Stabilization of mRNA in an Escherichia coli cell-free translation system, FEBS Letters, 321(2,3):169, Apr. 1993.
Khan and Coulson, A novel method to stabilise antisense oligonucleotides against exonuclease degradation, Nucleic Acids Research, 21(12):2957, 1993.
Akira Murakami, Basic of Antisense Molecules, Journal of Clinical and Experimental Medicine, 170(13):1994.
Tang, et al., Self-stabilized antisense oligodeoxynucleotide phosphorothioates: properties and anti-HIV activity, Nucleic Acids Research, 21(11):2729, 1993.

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