Halogenated triptolide derivatives as immunomodulators and...

Details Halogenated triptolide derivatives as immunomodulators and... Halogenated triptolide derivatives as immunomodulators and...

2005-09-13

2005-09-13

Trinh, Ba K. (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

active

06943259

ABSTRACT:
Compounds having the structure I:are useful for inducing cell death (apoptosis) and in immunosuppression. In structure I,CR1R2is selected from CHOH, C═O, CHF, CF2and C(CF3)OH;CR6and CR13are selected from CH, COH and CF;CR7R8, CR9R10and CR11R12are selected from CH2, CHOH, C═O, CHF and CF2; andCR3R4R5is selected from CH3, CH2OH, C═O, COOH, CH2F, CHF2and CF3;such that: at least one of R1-R13comprises fluorine;no more than two of CR3R4R5, CR6, CR7R8, CR9R10, CR11R12, and CR13comprises fluorine or oxygen;and, when CR1R2is CHOH, CR3R4R5is not CH2F.

REFERENCES:
patent: 5430054 (1995-07-01), Qian et al.

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