Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acids and salts thereof
Reexamination Certificate
2006-06-27
2006-06-27
Tsang, Cecilia J. (Department: 1625)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carboxylic acids and salts thereof
C562S433000, C562S442000, C562S443000, C514S579000
Reexamination Certificate
active
07067694
ABSTRACT:
Compounds of the general formula (I)wherein R1represents halogen, R2and R3represent H or halogen, and R4represents C3-8-cycloalkyl or optionally substituted phenyl, pharamceutical compositions containing such materials, and methods of using such materials in the treatment of various diseases are disclosed and claimed.
REFERENCES:
patent: 6166027 (2000-12-01), Straub et al.
patent: 6180656 (2001-01-01), Furstner et al.
patent: 6387940 (2002-05-01), Straub et al.
patent: 6451805 (2002-09-01), Straub et al.
patent: 2387107 (2001-03-01), None
patent: 19943635 (2001-03-01), None
patent: 19943635 (2001-03-01), None
patent: 0345068 (1989-12-01), None
patent: 9300359 (1993-01-01), None
patent: 9816223 (1998-04-01), None
patent: 9816507 (1998-04-01), None
patent: 9823619 (1998-06-01), None
patent: 0119355 (2001-03-01), None
patent: 0119776 (2001-03-01), None
patent: 0119778 (2001-03-01), None
patent: 0119780 (2001-03-01), None
Ko et al., YC-1, a Novel Activator of Platelet Guanylate Cyclase, Blood, 84, 4226-4233 (1994).
Mulsch, et al., Effect of YC-1, an NO-independent, Superoxide-Sensitive Stimulator of Soluble Gunanylyl Cyclase, on Smooth Muscle Responsiveness to Nitrovasodilators, Brit. J. Pharm. 120, 681-689 (1997).
Glass et al., Stimulation of Human Platelet Guanylate Cyclase by Fatty Acids, J. Biol. Chem., 252, 1279-1285 (1977).
Pettibone et al., A Structurally Novel Stimulator of Guanylate Cyclase with Long-lasting Hypotensive Activity in the Dog, European J. Pharm. 116, 307-312 (1985).
Yu et al., Vasorelaxant Effect of Isoliquiritigenin, a Novel Soluble Guanylate Cyclase Acitvator , in Rat Aorta, Brit. J. Pharm. 114, 1587-1594 (1995).
Gerzer, et al. Soluble Guanylate Cyclase Purified From Bovine Lung Contains Herne and Copper, FEBS letters, 132, 71-74 (1981).
Hoenicka, et al. Purified Soluble Guanylyl Cyclase expressed in Baculovirus/Sf9 system: stimulation by YC-1, nitric oxide, and carbon monoxide J. Mol. Med., 77, 14-23, (1999).
Ignarro, Louis J., Regulation of Cytosolic Guanylyl Cyclase By Porphyrins and Metalloporphyrins, Advances in Pharmacol., 26, 35-65 (1994).
Pinzani, Massino. M.D.; Biology of Hepalc Stellate Cells and Their Possible Relevance in the Pathogenesis of Portal Hypertension in Cirrhosis, Seminars in Liver Disease, 19, 397-410 (1999).
Mülsch, et al., Potentiation of Vascular Responses to NO-Donors by an NO-independent Activation of Soluble Guanylyl Cyclase, Naunyn Schmiedebergs Arch. Pharmacol. 355, R47.
Ko et al., YC-1 a Novel Activator of Platelet Guanylate Cyclase, Blood, 84, 4226-4233 (1994).
Mülsch, et al., Effect of YC-1, an NO-independent, Superoxide-Sensitive Stimulator of Soluble Guanylyl Cyclase, on Smooth Muscle Responsiveness to Nitrovasodilators, Brit. J. Pharm. 120, 681-689 (1997).
Glass et al., Stimulation of Human Platelet Guanylate Cyclase by Fatty Acids, J. Biol. Chem., 252, 1279-1285 (1977).
Pettibone et al., A Structurally Novel Stimulator of Guanylate Cyclase with Long-lasting Hypotensive Activity in the Dog, European J. Pharm. 116, 307-312 (1985).
Yu et al., Vasorelaxant Effect of Isoliquiritigenin, a Novel Soluble Guanylate Cyclase Activator, in Rat Aorta, Brit. J. Pharm. 114, 1587-1594 (1995).
Gerzer, et al. Soluble Guanylate Cyclase Purified From Bovine Lung Contains Heme and Copper, FEBS letters, 132, 71-74, (1981).
Hoenicka, et al. Purified Soluble Guanylyl Cyclase expressed in Baculovirus/Sf9 system: stimulation by YC-1, nitric oxide, and carbon monoxide J. Mol. Med., 77, 14-23, (1999).
Ignarro, Louis J., Regulation of Cytosolic Guanylyl Cyclase By Porphyrins and Mettaloporphyrins, Advances in Pharmacol., 26, 35-65 (1994).
Pinzani, et al; Biology of Hepatic Stellate Cells and Their Possible Relevance in the Pathogenesis of Portal Hypertension in Cirrhosis, Seminars in Liver Disease, 19, 397-410, (1999).
Mülsch, et al., Potentiation of Vascular Responses to NO-Donors by and NO-independent Activation of Soluble Guanylyl Cyclase, Naynym Schmiedebergs Arch. Pharmacol. 355, R47.
Hahn Michael G.
Härter Michael
Hirth-Dietrich Claudia
Knorr Andreas
Stahl Elke
Bayer Aktiengesellschaft
Reyes Hector M.
Tsang Cecilia J.
LandOfFree
Halogen-substituted amino dicarboxylic acid derivatives as... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Halogen-substituted amino dicarboxylic acid derivatives as..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Halogen-substituted amino dicarboxylic acid derivatives as... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3658984