Halo-substituted pyrimidodiazepines

Details Halo-substituted pyrimidodiazepines Halo-substituted pyrimidodiazepines

2011-08-23

2011-08-23

Kifle, Bruck (Department: 1622)

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

Reexamination Certificate

active

08003785

ABSTRACT:
The present invention provides PLK1 inhibitor compounds of formula I:useful in the treatment or control of cell proliferative disorders, particularly oncological disorders. These compounds and formulations containing such compounds may be useful in the treatment or control of solid tumors, such as, for example, breast, colon, lung and prostate tumors and other oncological diseases such as non-Hodgkin's lymphomas. Also provided are intermediate compounds useful in the synthesis of compounds of formula I.

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Haugwitz et al., J. Med. Chem., 25, pp. 969-974 (1982).

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