Halo substituted .beta.-lactam antibiotics

Details Halo substituted .beta.-lactam antibiotics Halo substituted .beta.-lactam antibiotics

1974-07-11

1977-02-15

Rizzo, Nicholas S.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260240A, 260240D, 2602391, 424246, 424271, C07D50116

Patent

active

040082296

ABSTRACT:
Imino chlorides of 6-aminopenicillanic esters and 7-aminocephalosporanic esters are reacted at a temperature between -80.degree. and -25.degree. C. with a strong base such as an alkali metal amide of a secondary amine and the generated anion is halogenated to provide the corresponding 6- or 7-halo-N(.alpha.-haloalkylidene) or N(.alpha.-halo-.alpha.-arylmethylidene)-6-aminopenicillanic or 7-aminocephalosporanic esters, respectively. The 6-halopenicillins and 7-halocephalosporins are converted to 6-methoxypenicillins and 7-methoxycephalosporins.

REFERENCES:
patent: 3325543 (1967-06-01), Degener et al.
patent: 3658792 (1972-04-01), Abe et al.
patent: 3832347 (1974-08-01), Kukolja et al.
patent: 3843641 (1974-10-01), Christensen et al.
patent: 3875146 (1975-04-01), Christensen et al.
patent: 3890310 (1975-06-01), Sapino, Jr. et al.

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