Hair growth stimulants

Details Hair growth stimulants Hair growth stimulants

1998-12-15

2001-02-27

Cook, Rebecca (Department: 1614)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

C-o-group doai

C514S729000, C514S880000, C514S307000

Reexamination Certificate

active

06194468

ABSTRACT:

FIELD OF THE INVENTION
The present invention relates to a hair growth stimulant. More specifically, the present invention relates to a hair growth stimulant which is free from hormonal action, does not cause side effects and has excellent pilatory effects.
BACKGROUND OF THE INVENTION
As hair growth stimulants, there have been disclosed a hair growth promoting composition (JP-B-2-2852; the term “JP-B” as used herein means an “examined Japanese patent publication”) comprising at least one substance selected from cinnamyl alcohol, cinnamyl alcohol esters, cinnamic acid and cinnamate compounds; and a hair growth stimulant (JP-B-3-844) which comprises 4,6,6-trimethylbicyclo(3.1.1)-hepten-3-one-2 as an active ingredient and capronium chloride, vitamin E nicotinate, benzyl nicotinate or the like used in combination as a blood circulation promoter (skin peripheral vasodepressor). It has been disclosed that since the latter one has inhibitory action against the formation of testosterone, which is a causative agent of excessive accumulation of androgen which will lead to physiological symptoms such as male pattern baldness and seborrhea, due to a reductase of 5&agr;-dihydrotestosterone, it is able to reduce or prevent such symptoms.
It has already been reported that p-menthane-3,8-diol to be used in the present invention is a substantially odorless compound which is contained in full-grown lemon eucalyptus in a small amount (
Phytochemistry,
23, 12, 2777(1984)).
It has been reported that p-menthane-3,8-diol heightens odor spreading and odor lasting properties (JP-A-4-337395; the term “JP-A” as used herein means an “unexamined published Japanese patent application) and it is effective as a repellent of noxious organisms (JP-B-3-80138), but there has no report on its effects of accelerating percutaneous absorption, thereby enhancing hair growth.
As a percutaneous absorption promoter containing a terpene, the following have been disclosed: a percutaneous absorption promoter (JP-A-6-48962) comprising a narcotic and/or non-narcotic analgesic and a terpene and/or an essential oil; and a percutaneous absorptive preparation for analgesic use (JP-A-9-143061), which contains, as a terpene, a hydrocarbon-based monoterpene such as limonene, a monoterpene alcohol such as 1-menthol, terpineol or borneol, a monoterpene aldehyde such as citral, a monoterpene ketone such as ionone or another monoterpene such as ceneole and/or, as an essential oil, mentha oil, peppermint oil or eucalyptus oil which is composed mainly of a terpene.
In addition, a percutaneous absorption preparation has been disclosed (JP-A-5-201879) which comprises triethylene glycol; and a terpene, for example, a monoterpene alcohol such as linalool, citronellol, geraniol, nerol, menthol, terpineol, carveol, thujyl alcohol, pinocampheol, cineole, dimethyl octanol, hydroxy citronellol, tetralinalool, muguol (produced by IFF), myrcenol or isopulegol or isomers thereof, a sesquiterpene alcohol such as farnesol, nerolidol, lanceol, santalol or vetivenol or optical or steric isomers thereof, nopol or bornyl methoxycyclohexanol and/or an essential oil, for example, bay oil, peppermint oil, orange oil, turpentine oil, lemon oil, hops oil, basil oil, evodia fruit oil, bitter orange peel oil, sweet orange oil, pine oil, camphor oil, zanthoxylum fruit oil, coriander oil, elemi oil, gingergrass oil, eucalyptus oil, fennel oil, chenopodium oil,
Cinnamomum kanahirai
oil, fragrant olive oil, savin oil,
Chamaecyperis obtusa
oil, orange flower oil, cymbopogon georingil oil, Japanese valerian oil, sandal wood oil, myrrh essential oil, ginger oil, turmeric oil, cedar wood oil, hinoki oil, celery seed essential oil, schisandra fruit oil, clove oil, cinnamon oil, geranium oil, lavender oil, rosemary oil, pepper oil, ylang—ylang oil, Kananga oil, perilla oil, patchouli oil, vetiver oil, spearmint oil or anise oil. As a medicament to be orally administered, dantrolene sodium, ketoprofen, diclofenac sodium or flurbiprofen is also disclosed.
Various compounds and extracts of a crude drug which have been conventionally known as a hair growth composition are employed as a hair growth stimulant. As a matter of fact, however, they do not always exhibit good effects for the hair growth, because conditions of the hair vary from person to person. Even if the hair growth composition is effective to some extent, it involves defects such as difficulty in continuous use because effects of epispastic or the like. The above-described percutaneous absorptive compositions permit the exhibition of hair growth promoting effects by transferring the medicament, which has been percutaneously administered as a liquid formulation, cream or ointment, to the necessary site, but they are not satisfactory.
SUMMARY OF THE INVENTION
An object of the present invention is therefore to provide a hair growth stimulant which is free from hormonal action, does not cause side effects and has excellent hair growth promoting effects.
With a view to attaining the above object, the present inventors carried out an extensive investigation. As a result, it has been found that p-menthane-3,8-diol has the action of promoting percutaneous absorption of a skin peripheral vasodepressor or hair growth promoting agent serving as a hair growth stimulant. It has also been found that hair growth promoting effects can be improved furthermore by using in combination said p-menthane-3,8-diol and at least one substance selected from a blood circulation promoter, a 5-&agr;-reductase inhibitor, an antihistaminic, a cell activator, an antiphlogistic and an antimicrobial. The present invention has been completed based on these findings.
The present invention concerns a hair growth stimulant comprising p-menthane-3,8-diol.
The present invention further concerns a hair growth stimulant, which comprises p-menthane-3,8-diol and at least one substance selected from the group consisting of a blood circulation promoter, a 5-&agr;-reductase inhibitor, an antihistaminic, a cell activator, an antiphlogistic, and an antimicrobial.
DETAILED DESCRIPTION OF THE INVENTION
The present invention will hereinafter be described more specifically.
p-Menthane-3,8-diol which is a compound to be used in the present invention can be synthesized by the ring closure of commercially available citronellal with sulfuric acid [see
J. Am. Chem. Soc.,
75, 2367(1953)]. It has isomers such as the cis-form, trans-form and optical isomers. They can be used either singly or in combination as a mixture.
p-Menthane-3,8-diol is easily soluble in a solvent for ordinarily used cosmetics, dermal compositions, hair growth stimulants or the like and can be incorporated therein freely. The amount of this substance is usually 0.01 to 20% by weight, preferably 0.1 to 15% by weight, more preferably 0.3 to 10% by weight based on the total amount of the cosmetic composition, dermal composition or hair growth stimulant as a final product. Amounts less than 0.01% do not bring about sufficient effects, while amounts exceeding 20% by weight do not bring about proportional effects.
The substance of the present invention can be incorporated as is or after being diluted with a solvent, perfume or essential oil contained therein, use of which is acceptable in the above-described cosmetic composition, dermal composition or hair growth stimulant.
Medicaments other than those with the above-described medicinal properties can be added as needed to the hair growth stimulant of the present invention. There is no particular limitation imposed on the kind of the medicament. Ordinarily-employed medicaments or coadjuvants can be used as are appropriate.
Examples of the skin peripheral vasodepressor (blood circulation promoter) or hair growth promoting agent include capronium chloride, vitamin E derivatives, cepharanthin, benzyl nicotinate, capsicum tincture,
swertiae herba
extract and
Spilanthes acmella
extract. They may be used either singly or in combination.
Examples of the 5-&agr;-reductase inhibitor include &bgr;-glycyrrhetic acid, estradiol and estrone; and th

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