Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector
Reexamination Certificate
2008-04-29
2008-04-29
Navarro, Mark (Department: 1645)
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Reexamination Certificate
active
10362458
ABSTRACT:
The present invention relates to a lipopolysaccharide moiety comprising a conserved triheptosyl inner-core moiety of lipopolysaccharide substantially free of variable outer core oligosaccharide chain extension, and to vaccines obtaines therefrom which are cross-reactive forHaemophilus influenzaestrains. The invention also relates to defined mutations in the biosynthetic machinery for lipopolysaccharide (LPS;) expression inHaemophilus influenzaeuseful to obtain the abovementioned moiety. The invention also relates to using conjugates of the LPS from the mutant strains so obtained to elicit a heterologous immune response against a wide range of disease-causingH. influenzaestrains. More specifically, the invention relates to vaccines for prevention of bacterial infections comprising core lipopolysaccharide ofHaemophilus influenzae.
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Cox Andrew
Hood Derek
Månsson Martin
Moxon Richard
Richards James C.
Archie Nina A.
M{dot over (a)}nsson Martin
National Research Council of Canada
Navarro Mark
Schweda Elke K. H.
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