H-Y antigen

Details H-Y antigen H-Y antigen

2006-03-07

2006-03-07

Nolan, Patrick J. (Department: 1644)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C530S327000, C530S328000, C424S185100

Reexamination Certificate

active

07008922

ABSTRACT:
The present invention relates to a peptide which is immunologically recognizable as a T cell epitope of the minor Histocompatibility antigen H-Y. The peptide comprises amino acid sequence SPSVDKARAEL (SEQ ID NO: 1) or FIDSYICQV (SEQ ID NO: 2). The peptide is obtainable from the minor Histocompatibility antigen H-Y. Providing a toxic moiety to the peptide eliminates T cells having specific binding affinity for the peptide. The peptide induces tolerance for transplantations when administered to H-Y-negative recipients.

REFERENCES:
Rufer, et al., “HA-1 and the SMCY-derived peptide FIDSYICQV (H-Y) are immunodominant minor histocompatibility antigens after bone marrow transplantation,” (1998) Transplantation, 66:910-916.
den Haan et al., “conservation of minor histocompatibility antigens between human and non-human primates,” (1996) Eur J Immunol., 26:2680-2685.
Agulnik et al., “Mouse H-Y encoding Smcy gene and its X chromosomal homolog Smcx,” (1999) Mammalian Genome, 10:926-929.
Janeway et al., Immunobiology, 3rdedition, Garland Publishing Inc., 1997, pp. 4:6-4:8 and G:15.
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Sireci et al, “Induction and Tolerization of anti-male CD8+ cytotoxic T lymphocytes by in vivo immunization with an H-Y-derived peptide” (1999) Human Immunology, 60:764-773.
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James et al. “Multiparity induces priming to male-specific minor histocompatibility antigen, HY, in mice and humans” (2003) Blood, 102:388-393.
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Wang W, Meadows LR, den Haan JMM, Sherman NE, Chen Y, Blokland E, Shabanowitz J, Agulink AI, Hendrickson RC, Bishop CE, Hunt DF, Goulmy E, Engelhard VH, “Human H-Y: A Male-Specific Histocompatibility Antigen Dervied from the SMCY Protein,”Science269:1588-1590 (1955).
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