Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1991-03-27
1992-11-24
Griffin, Ronald W.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
514886, 514887, 514921, A61K 3170, A61K 31715
Patent
active
051661373
ABSTRACT:
A family of compounds effective in inhibiting interleukin-1 (IL-1) production, interleukin-6 (IL-6), tumor necrosis factor (TNF) production, and the production of other leukocyte derived cytokines is comprised of oligomers and polymers of .alpha.1-4 linked L-guluronic acid residues which may be administered to a human or mammal in an amount sufficient to inhibit the production effect of leukocyte-derived cytokines. The inhibition of IL-1, IL-6 and TNF, and other cytokines in mammals is implicated in alleviation of a wide variety of disease conditions.
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Espevik Terje
Otterlei Marit
Skjak-Braek Gudmund
Smidsrod Olav
Griffin Ronald W.
Nobipols Forskningsstiftelse
Protan Biopolymer A/S
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