Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Oxidoreductase
Patent
1996-12-26
1998-05-26
Wax, Robert A.
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Oxidoreductase
435191, 4352523, 43525233, 4353201, 536 231, 536 232, 536 235, C12N 902, C12N 120
Patent
active
057563322
ABSTRACT:
The present invention provides a human guanosine monophosphate reductase (HGMPR) and polynucleotides which identify and encode HGMPR. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding HGMPR and a method for producing HGMPR. The invention also provides for agonists, antibodies, or antagonists specifically binding HGMPR, and their use, in the prevention and treatment of diseases associated with expression of HGMPR. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding HGMPR for the treatment of diseases associated with the expression of HGMPR. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding HGMPR.
REFERENCES:
Kanno, H et al., "Two Structural Genes on Different Chromosomes Are Required for Encoding the Major Subunit of Human Red Cell Glucose-6-Phosphate Dehydrogenase" Cell 58:595-606 (1989).
Streeter, DG and Robins, RK, "Comparative In Vitro Studies of Tiazofurin and a Selenazole Analog" Biochem. Biophys. Res. Comm. 115(2):544-550 (1983).
Page, T et al., "Studies on the mechanism of cytotoxicity of 3-deazaguanosine in human cancer cells" Cancer. Chemother Pharmacol 15:59-62 (1985).
Prajda, N et al., "Sequential Impact of Tiazofurin and Ribavirin on the Enzymic Program of the Bone Marrow" Cancer Research 53:5982-5986 (1993).
Franklin, TJ et al., "The Inhibition of Nucleic Acid Synthesis by Mycophenolic Acid" Biochem. J. 113:515-524 (1969).
Andrews, SC and Guest, JR, "Nucleotide sequence of the gene encoding the GMP reductase of Escherichia coli K12" Biochem J 255:35-43 (1988) (GI 473772).
Kondoh, T et al., "Genomic structure and expression of human guanosine monophosphate reductase" Hum Genet 88:219-224 (1991) (GI 544455).
Billings Lucy J.
Incyte Pharmaceuticals Inc.
Nashed Nashaat T.
Wax Robert A.
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