Surgery – Means for introducing or removing material from body for... – Treating material introduced into or removed from body...
Patent
1999-03-22
2000-10-24
McDermott, Corrine
Surgery
Means for introducing or removing material from body for...
Treating material introduced into or removed from body...
600365, 607 72, A61M 3100
Patent
active
061359785
ABSTRACT:
There is provided an implantable system and method for monitoring pancreatic beta cell electrical activity in a patient in order to obtain a measure of a patient's insulin demand and blood glucose level. A stimulus generator is controlled to deliver stimulus pulses so as to synchronize pancreatic beta cell depolarization, thereby producing an enhanced electrical signal which is sensed and processed. In a specific embodiment, the signal is processed to determine the start and end of beta cell depolarization, from which the depolarization duration is obtained. In order to reduce cardiac interference, each stimulus pulse is timed to be offset from the QRS signal which can interfere with the pancreas sensing. Additionally, the beta cell signals are processed by a correction circuit, e.g., an adaptive filter, to remove QRS artifacts, as well as artifacts from other sources, such as respiration. The thus obtained insulin demand signal is used either to control delivery of insulin from an implanted insulin pump, or to control ongoing pancreatic stimulation of a form to enhance insulin production.
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"Kinetics of Intraperitoneally Infused Insulin in Rats--Functional Implications for the Bioartificial Pancreas"--Paul De Vos et al. (Diabetes, vol. 45, Aug. 1996).
Pancreatic Beta Cells are Bursting, but how?--Daniel L. Cook, et al. (TINS, vol. 14, No. 9, 1991).
Houben Richard P. M.
Renirie Alexis C. M.
Weijand Koen J.
Jaro Michael J.
McDermott Corrine
Medtronic Inc.
Patton Harold
Woods Thomas F.
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