Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Parasitic organism or component thereof or substance...
Patent
1979-12-27
1981-08-11
Berch, Mark L.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Parasitic organism or component thereof or substance...
548193, 548196, 548197, C07D27738, A61K 31425
Patent
active
042834082
ABSTRACT:
Novel guanidinothiazole compounds of the general formula ##STR1## wherein R represents a hydrogen atom or a lower alkyl group, R.sub.1 represents an amino group, a lower alkyl group, a halogeno lower alkyl group, a substituted- or unsubstituted-aryl group, a mono- or di-lower alkylamino group, an arylamino group or an aralkylamino group, R.sub.2 represents a hydrogen atom, a lower alkyl group, a lower alkenyl group or a lower alkynyl group, Y represents a sulfur atom or a methylene group, m and n, each represents an integer of 1-3, and the pharmacologically acceptable acid addition salts thereof, they are useful as gastric acid secretion inhibitors.
REFERENCES:
patent: 3950333 (1976-04-01), Durant et al.
patent: 4165377 (1979-08-01), Jones et al.
patent: 4165378 (1979-08-01), Gilman
Miyazaki et al., Chem. Ab 48, 8259h.
Knott, J. Chem. Soc. 1945, 686.
Cooper et al., J. Chem. Soc. 1952, 5036.
Hirata Yasufumi
Ishii Yoshio
Isomura Yasuo
Ito Noriki
Takeda Masaaki
Berch Mark L.
Yamanouchi Pharmaceutical Co. Ltd.
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