Guanidine derivatives

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514183, 514211, 514212, 514220, 5142355, 514307, 514312, 514314, 514316, 514319, 514321, 514331, 514822, 540481, 540506, 540544, 540573, 540597, 544130, 544162, 544168, A61K 31445, C07D21122, C07D21126, C07D40112

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active

053937600

ABSTRACT:
Compounds of the formula ##STR1## wherein L, M, R, T and X are set forth in the description, as well as hydrates or solvates thereof, which inhibit thrombin-induced platelet aggregation and clotting of fibrinogen in plasma, are described. The compounds of formula I are prepared by amidination or, depending on whether L is NH or O, by amide formation or esterification.

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patent: 5260307 (1993-11-01), Ackermann et al.
J. Med. Chem. 23, 1980, 1293-9, Kikumoto et al.
Pharmazie 39, 1984, 226-230, Wagner et al.

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