Growth of hepatitus A virus in vero cells

Details Growth of hepatitus A virus in vero cells Growth of hepatitus A virus in vero cells

1985-09-30

1988-11-08

Kepplinger, Esther M.

Chemistry: molecular biology and microbiology

Virus or bacteriophage, except for viral vector or...

424 89, C12N 700, A61K 3929

Patent

active

047834072

ABSTRACT:
Hepatitus A virus is grown in Vero cells after passage in in vitro cell culture. Virus replication and continued passage in Vero cells requires extended incubation times, up to about four weeks, for early passages and incubation temperatures no higher than about 32.degree. C. Continued passage results in a significant decrease in incubation time and an increase in virus yield. Cultivation of hepatitus A virus in Vero cells meets the development requirements for an inactivated human vaccine.

REFERENCES:
patent: 4164566 (1979-08-01), Provost et al.
patent: 4301249 (1980-07-01), Markus et al.
Kojima et al., J. of Med. Virol., 7:273-286 (1981).
Locarini et al., J. of Virol., 37:216-225 (1981).
Provost, In Vitro Propagation of Hepatitus A Virus, in Gerety (ed.) Hepatitus A, Academic Press (1984).

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