Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Lymphokines – e.g. – interferons – interlukins – etc.
Patent
1984-08-31
1987-12-29
Hazel, Blondel
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Lymphokines, e.g., interferons, interlukins, etc.
424 85, 435 68, 435811, C07K 1300, C07K 1526, A61K 4502
Patent
active
047162171
ABSTRACT:
DNA sequences encoding for novel human lymphoblastoid-leukocyte hybrid interferons. Methods of making nucleotide sequences comprising ribosome binding sites, promoter regions, and segments of human lymphoblastoid and leukocyte interferons are described. DNA sequences for hybrid interferons are cloned and expressed in plasmid vectors. Transformed microorganisms and novel lymphoblastoid-leukocyte polypeptide interferons having biological or immunological activity are disclosed.
REFERENCES:
patent: 4414150 (1983-11-01), Goeddel
patent: 4569908 (1986-02-01), Mark et al.
Shepard et al., Nature, vol. 294, pp. 563-565, 1981.
Caruthers Marvin H.
Leineweber Michael
Leitner Moshe
Stabinsky Yitzhak
Hazel Blondel
Monahan Thomas J.
University Patents Inc.
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