Growth hormone crystals and a process for production of...

Details Growth hormone crystals and a process for production of... Growth hormone crystals and a process for production of...

2005-05-17

2005-05-17

Carlson, Karen Cochrane (Department: 1653)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C530S399000, C530S420000, C530S422000, C530S305000

Reexamination Certificate

active

06894023

ABSTRACT:
A process for producing cation crystals of growth hormone or growth hormone derivatives, as well as growth hormone and growth hormone derivatives. The process of producing the growth hormone crystals includes the steps of (a) adding cations of inorganic or organic nature and an organic solvent or a mixture of inorganic solvents at a pH between 5.0 and 6.8 to a solution of growth hormone or derivatives. (b) growing growth hormone crystals at a temperature from about 0 to 30° C. and (c) isolating the cation crystals.

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J. Clarkson et al., J. Mol., Biol., vol. 208, pp. 719-721 (1989).

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