Graminae pollen allergen mutants for specific immunotherapy,...

Details Graminae pollen allergen mutants for specific immunotherapy,... Graminae pollen allergen mutants for specific immunotherapy,...

2005-07-19

2005-07-19

Nolan, Patrick J. (Department: 1644)

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Allergen or component thereof

C424S185100, C530S379000, C514S012200

Reexamination Certificate

active

06919086

ABSTRACT:
The invention relates to modified recombinant allergen mutants which can be obtained from recombinant allergens which are derived from allergens which can be obtained by extraction from natural raw materials such as pollen of the speciesPhleum pratense.While these modified recombinant allergens stimulate lymphocytes from patients who are allergic to pollent to proliferate and synthesize cytokines, they exhibit a markedly diminished ability to bind to the IgE antibodies which are present in the serum of the T lymphocyte donors and to grass pollen allergen-specific IgEs and can therefore be used for a specific, made-to-release allergy therapy.

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