GPIb-lipid bond construct and use thereof

Details GPIb-lipid bond construct and use thereof GPIb-lipid bond construct and use thereof

2005-08-09

2005-08-09

Russel, Jeffrey Edwin (Department: 1654)

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

In an organic compound

C424S009100, C424S009340, C424S009400, C424S009600, C514S005200, C514S006900, C514S007600, C514S008100, C514S021800, C530S381000, C530S395000, C530S408000, C530S409000, C530S410000

Reexamination Certificate

active

06926884

ABSTRACT:
The present invention provides a conjugate wherein GP (glycoprotein) Ib and a lipid are bonded via polyalkylene oxide. The present invention also provides a complex (GPIb lipid complex) containing this conjugate and a free lipid. The GPIb lipid complex is expected to have a potential for practical application in a wide range, as a platelet substitute, a pharmaceutical agent for the prophylaxis or treatment of angiopathy, vascular damage and thrombosis, a diagnostic for vWF deficiency and the like, a biological or medical reagent, a reagent for screening platelet aggregation suppressant or antithrombosis, and the like. The GPIb lipid complex of the present invention is also useful as a diagnostic for finding the location of vascular lesion or thrombus formation, or a therapeutic agent thereof. Moreover, the GPIb lipid complex of the present invention is also superior in retention property in blood, which enables continuous expression of a pharmacological action. The conjugate of the present invention is highly utilizable as an active ingredient of the GPIb lipid complex of the present invention.

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