Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2007-02-13
2007-02-13
Rao, Deepak (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C544S311000
Reexamination Certificate
active
11251085
ABSTRACT:
GnRH receptor antagonists are disclosed that have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure:wherein R1a, R1b, R1c, R2a, R2b, R3, R4, R5, R6and X are as defined herein, including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof.
REFERENCES:
patent: 6608197 (2003-08-01), Zhu et al.
patent: 2005/0038056 (2005-02-01), Huang et al.
patent: 2005/0043338 (2005-02-01), Zhu et al.
patent: WO 96/38438 (1996-12-01), None
patent: WO 97/14682 (1997-04-01), None
patent: WO 97/14697 (1997-04-01), None
patent: WO 97/21435 (1997-06-01), None
patent: WO 97/21703 (1997-06-01), None
patent: WO 97/21704 (1997-06-01), None
patent: WO 97/21707 (1997-06-01), None
patent: WO 98/55116 (1998-12-01), None
patent: WO 98/55119 (1998-12-01), None
patent: WO 98/55470 (1998-12-01), None
patent: WO 98/55479 (1998-12-01), None
patent: WO 99/09033 (1999-02-01), None
patent: WO 00/69859 (2000-11-01), None
patent: WO 01/29044 (2001-04-01), None
patent: WO 01/55119 (2001-08-01), None
patent: WO 02/11732 (2002-02-01), None
patent: WO 02/066459 (2002-08-01), None
patent: WO 03/011293 (2003-02-01), None
patent: WO 03/011839 (2003-02-01), None
patent: WO 03/011841 (2003-02-01), None
patent: WO 03/011870 (2003-02-01), None
patent: WO 03/013528 (2003-02-01), None
Cho, N., et al. “Discovery of a Novel, Potent, and Orally Active Nonpeptide Antagonist of the Human Luteinizing Hormone-releasing Hormone (LHRH) Receptor,”J. Med. Chem. 41(22):4190-5, Oct. 22, 1998.
Huime, J., et al., “Gonadotropin-releasing-hormone-receptor Antagonists,”Lancet. 358(9295):1793-803, Nov. 24, 2001.
McCartney, C., et al., “Regulation of gonadotropin secretion: implications for polycystic ovary syndrome,”Semin Reprod Med., 20(4):317-26, Nov. 2002.
Olivennes, F., et al., The Use of GnRH Antagonists in Ovarian Stimulation,Hum Reprod Update, 8(3):279-90, May-Jun. 2002.
Simone, Oncology: Introduction, Cecil Textbook of Medicine, 20thed., vol. 1, pp. 1004-1010, 1996.
Zhu, Y-F., et al., “Identification of 1-arylmethyl-3-(2-aminoethyl)-5-aryluracil as Novel Gonadotropin-releasing Hormone Receptor Antagonists,”J. Med. Chem. 46(11):2023-6, May 22, 2003.
Chen Chen
Chen Yongsheng
Dwight Wesley J.
Guo Zhiqiang
Huang Charles Q.
Neurocrine Biosciences Inc.
Rao Deepak
Seed IP Law Group PLLC
LandOfFree
Gonadotropin-releasing hormone receptor antagonists and... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Gonadotropin-releasing hormone receptor antagonists and..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Gonadotropin-releasing hormone receptor antagonists and... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3894541