Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Lyase
Reexamination Certificate
2005-06-28
2005-06-28
Prouty, Rebecca (Department: 1652)
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Lyase
C435S007400, C435S174000, C435S194000, C435S015000, C530S387300, C530S412000, C530S388230, C530S350000, C536S023200
Reexamination Certificate
active
06911336
ABSTRACT:
The present invention discloses a novel polypeptide that contains an amino acid decarboxylase domain, and is a substrate for caspase-3. Nucleic acids that encode the novel polypeptide and antibodies to the polypeptide are also part of the present invention. Methods of using the polypeptide, the nucleic acids and antibodies are also provided.
REFERENCES:
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patent: WO 00/36097 (2000-06-01), None
patent: WO 01/22920 (2001-04-01), None
patent: WO 01/53312 (2001-07-01), None
patent: WO 01/53455 (2001-07-01), None
patent: WO 00/55174 (2001-09-01), None
Vito P. et al. Generation of Anti-apoptotic Presenilin-2 Polypeptides by Alternative Transcription, Proteolysis, and Caspase-3 Cleavage, J. Biol. Chem., 1997, 272, 28315-28320.
Graves J. D. et al. Caspase-mediated activation and induction of apoptosisby the mammalian Ste20-like kinase Mst1, EMBO J. 1998, 17, 2224-2234.
Database EMBL-EBI [Online}, European Information Institute, Hinxton, UK; Apr. 25, 1997, Ohara et al., “Human mRNA for KIAA0251, partial cds.;”, Database accession No. D87438.
Nagase et al., DNA Research, 3:321-329 (1996).
Bird Timothy A.
Garka Kirsten
Holland Pamela M.
Virca G. Duke
Immunex Corporation
Levy Ron K.
Prouty Rebecca
Tran Paul B.
Walicka Malgorzata A.
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