Glycolipid mimics and methods of use thereof

Details Glycolipid mimics and methods of use thereof Glycolipid mimics and methods of use thereof

1996-11-22

1999-10-26

Fonda, Kathleen K.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 179, 536 187, 5361231, 514 25, 514 54, C07H 1500, A61K 3170

Patent

active

059731281

ABSTRACT:
Glycolipid mimics which include a rigid hydrophobic moiety are disclosed. Methods of using the glycolipid mimics are also disclosed.

REFERENCES:
patent: 4359460 (1982-11-01), Nair et al.
patent: 4859769 (1989-08-01), Karlsson et al.
patent: 4868289 (1989-09-01), Magnusson et al.
patent: 5164298 (1992-11-01), Lingwood et al.
patent: 5242800 (1993-09-01), Jimenez et al.
patent: 5399567 (1995-03-01), Platt et al.
Lingwood, C.A. "Verotoxins and Their Glycolipid Receptors" Advances in Li Research 25:189-211 (1993).
Berge et al. "Pharmaceutical Salts" Journal of Pharmaceutical Sciences 66(1):1-19 (Jan. 1977).
Boyd, B. et al. "Lipid modulation of glycolipid receptor function. Availability of Gal(.alpha.1-4)Gal disaccharide for verotoxin binding in natural and synthetic glycolipids" Eur. J. Biochem. 223:873-878 (1994).
Fenderson, B.A. et al. "Glycoconjugate expression during embryogenesis and its biological significance" BioEssays 12(4):173-179 (Apr. 1990).
Hakomori, S. "Bifunctional role of glycosphingolipids" The Journal of Biological Chemistry 265(31):18713-18716 (Nov. 1990).
Hakomori, S. et al. "Glycosphingolipids as tumor-associated and differentiation markers" Jounal ot the National Caner Institute (JNCI) 71(2):231-251 (Aug. 1983).
Kiarash, A. et al. "Glycosphingolipid receptor function is modified by fatty acid content. Verotoxin 1 and Verotoxin 2c preferentially recognize different globotriaosyl ceramide fatty acid homologues" The Journal of Biological Chemistry 269(15):11138-11146 (Apr. 1994).
Kundu, S.K. et al. "Aminopropyl silica gel as a solid support for prepartion of glycolipid immunoadsorbent and purification of antibodies" Journal of Lipid Research 20:825-833 (1979).
Laine, R. et al. "Glycosphingolipids covalently liked to agarose gel or glass beads" The Journal of Biological Chemistry 249(14):4460-4466 (Jul. 1974).
Lingwood, C. et al. "Synthesis and use of galactolipid sulfotransferase substrate-analogue affinity probes: possible localization of the testicular enzyme" Biochem. Cell Biol. 64:631-637 (1986).
MacDonald, D.L. et al. "Notes on improved procedure for the chemical modification and degradation of glycosphinglipids" Journal of Lipid Researcj 21:642-645 (1980).
Pagano, R. et al. "A series of fluorescent N-acylsphingosines: synthesis, physical properties, and studies on cultured cells" Biochemistry 27:4439-4445 (1988).
Pellizzari, A. et al. "Binding of Verocytotoxin 1 to its receptor is influenced by differences in receptor fatty acid content" Biochemistry 31:1363-1370 (1992).
Sakac, D. et al. "Purification of the testicular galactolipid: 3'-phosphoadenosine 5' phosphosulfate sulfotransferase" The Journal of Biological Chemistry 267(3):1655-1659 (Jan. 1992).
Sonnino, S. et al. "Preparation of GM 1 ganglioside molecular species having homogeneous fatty acid and long chain base moieties" Journal of Lipid Research 26:248-257 (1985).
Ono et al. Chemistry Letters 1991, 3, 395-398. month not available.
Nagai et al. Bull. Chem. Soc. Jpn. Oct. 1993, 66(10), 2965-2971.

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