Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert
Patent
1997-06-30
1999-04-06
Azpuru, Carlos A.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Implant or insert
5147723, 514777, A61R 202, A61K 4730, A01N 2512
Patent
active
058914560
ABSTRACT:
A method to administer a drug locally to a subject in which biodegradable dosage forms that contain the drug are implanted at a localized site beneath the skin of the subject whereupon the dosage forms release the drug over a desired period of time at a substantially continuous rate. Glyceryl monostearate based compositions that accomplish the method are also provided. Compositions are further provided that affect the release profile or release duration of drugs that are released from the compositions, as are methods that employ these varying release profiles to provide implantable dosage forms that release drugs at a prescribed rate over a prescribed period of time. The compositions are particularly well adapted to implantable dosage forms because they biodegrade quickly to an acceptable level after delivering the drug.
REFERENCES:
patent: 3374146 (1968-03-01), Blicharz et al.
Milojevic et al., "Amylose as a Coating for Drug Delivery to the Colon: Preparation and In Vitro Evaluation Using Glucose Pellets," Journal of Controlled Release, 38 (1996) 85-94.
Peri et al., "Development of an Implantable, Biodegradable, Controlled Drug Delivery System for Local Antibiotic Therapy," Drug Development and Industrial Pharmacy, 20(8) (1994) 1334-1352.
Nishihata, "Use of Enzymatic Activity for Design of Orally Administered Enteric Dosing Form, " Journal of Pharmaceutical Pharmacology, 45 (1993) 947-950.
Allababidi Saleh
Shah Jaymin C.
Azpuru Carlos A.
Medical University of South Carolina
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