Glucopyranosyloxypyrazole derivatives and medicinal use thereof

Details Glucopyranosyloxypyrazole derivatives and medicinal use thereof Glucopyranosyloxypyrazole derivatives and medicinal use thereof

2007-03-13

2007-03-13

Jiang, Shaojia Anna (Department: 1623)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C514S025000, C514S035000, C536S004100, C536S017200, C536S017400, C536S018100

Reexamination Certificate

active

11358400

ABSTRACT:
The present invention provides glucopyranosyloxypyrazole derivatives represented by the general formula:wherein one of Q and T represents a group represented by the general formula:while the other represents a lower alkyl group or a halo(lower alkyl) group; R1represents a hydrogen atom, an optionally substituted lower alkyl group, a lower alkenyl group, a cyclic lower alkyl group, etc.; R2represents a hydrogen atom, an optionally substituted lower alkyl group, a lower alkoxy group, a lower alkenyl group, a cyclic lower alkyl group, a cyclic lower alkoxy group, etc., which exert an excellent inhibitory activity in human SGLT2, and therefore are useful as drugs for the prevention or treatment of a disease associated with hyperglycemia such as diabetes, diabetic complications or obesity, pharmaceutically acceptable salts thereof or prodrugs thereof, production intermediates thereof and pharmaceutical uses thereof.

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