Glucopyranosyloxybenzylbenzene derivatives, medicinal...

Details Glucopyranosyloxybenzylbenzene derivatives, medicinal... Glucopyranosyloxybenzylbenzene derivatives, medicinal...

2006-05-16

2006-05-16

Wilson, James O. (Department: 1623)

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

C568S300000, C568S700000, C568S715000, C568S716000, C568S731000, C568S732000, C568S743000

Reexamination Certificate

active

07045665

ABSTRACT:
The present invention relates to benzylphenol derivatives represented by the general formula:wherein R11represents a hydrogen atom or a protected hydroxy(lower alkyl) group; and R12represents a lower alkyl group, a lower alkoxy group, a lower alkylthio group, a protected hydroxy(lower alkyl) group, a protected hydroxy(lower alkoxy) group, a protected hydroxy(lower alkylthio) group, a lower alkoxy-substituted (lower alkyl) group, a lower alkoxy-substituted (lower alkoxy) group or a lower alkoxy-substituted (lower alkylthio) group; with the proviso that R12is not a methyl group, an ethyl group, an isopropyl group, a tert-butyl group or a methoxy group when R11is a hydrogen atom, or a salt thereof, which are used as intermediates for making glucopyranosyloxybenzylbenzene compounds having inhibitory activity in human SGLT2 and are useful in treating diseases associated with hyperglycemia, such as diabetes.

REFERENCES:
patent: 4598068 (1986-07-01), Samreth et al.
patent: 6683056 (2004-01-01), Washburn et al.
patent: 2002/0111315 (2002-08-01), Washburn et al.
patent: WO 01/74834 (2001-10-01), None
Kanala et al., “Hydrogen Bonding in Phenols—XI”, Tetrahedron, vol. 31, pp. 2089-2090, 1975.

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