Surgery – Diagnostic testing – Detecting nuclear – electromagnetic – or ultrasonic radiation
Reexamination Certificate
2006-05-16
2006-05-16
Farah, A. (Department: 3739)
Surgery
Diagnostic testing
Detecting nuclear, electromagnetic, or ultrasonic radiation
C606S009000, C606S010000, C359S368000, C359S385000, C359S656000
Reexamination Certificate
active
07047064
ABSTRACT:
An imaging apparatus is provided for imaging tissue samples substantially beneath the surface of the tissue sample. The apparatus includes an objective lens and a window defining a tissue contacting surface in pressure contacting relationship with the surface of the tissue sample when the tissue sample is imaged by the objective lens to view tissue structures for pathological applications. The objective lens focuses an illumination beam through the window to the tissue sample and receives returned reflected light of the beam representative of one or more sections of the tissue sample. The apparatus enables a method for in vivo observation of tissue for diagnosis of conditions substantially beneath the surface of the tissue sample. Both two and three-dimensional imaging may be provided for diagnosis and location of basal cell carcinomas and melanomas, and so as to enable visualization of tumor borders prior to excision.
REFERENCES:
patent: 4768874 (1988-09-01), Webb et al.
patent: 4817622 (1989-04-01), Pennypacker et al.
patent: 4863252 (1989-09-01), McCarthy et al.
patent: 4965441 (1990-10-01), Picard
patent: 4991953 (1991-02-01), Pflibsen et al.
patent: 5048904 (1991-09-01), Montagu
patent: 5048942 (1991-09-01), Ohbayashi
patent: 5120953 (1992-06-01), Harris
patent: 5122653 (1992-06-01), Ohki
patent: 5321683 (1994-06-01), Olczak
patent: 5386317 (1995-01-01), Corle et al.
patent: 5464436 (1995-11-01), Smith
patent: 5532874 (1996-07-01), Stein
patent: 5557452 (1996-09-01), Harris
patent: 5699798 (1997-12-01), Hochman et al.
patent: 5719700 (1998-02-01), Corcuff et al.
patent: 5788639 (1998-08-01), Zavislan et al.
patent: 5880880 (1999-03-01), Anderson et al.
patent: 5995283 (1999-11-01), Anderson et al.
patent: 6032071 (2000-02-01), Binder
patent: 6263233 (2001-07-01), Zavislan et al.
patent: 0 683 386 (1995-05-01), None
patent: 8-140961 (1994-06-01), None
Charles J. Koester, “Scanning mirror microscope with optical characteristics: applications in Ophthalmology,” Appl. Opt. vol. 19, No. 11, Jun. 1980.
Charles J. Koester, “Scanning mirror microscope with optical characteristics: applications in ophthalmology,” Appl. Opt. vol. 19, No. 11, Jun. 1980.
Maurice D. “Cellular Membrane Activity in the Corneal Endothelium of the Intact eye,” Experientia, vol. 24, pp. 1094-1095, (1968).
Maurice, D., Cellular Membrane Activity in the Corneal Endothelium of the Intact Eye, Experientia, vol.24, pp. 1094-1095, (1968).
Maurice, D., A Scanning Slit Optical Microscope, Investigative Ophthalmology, vol. 13, No. 12, pp. 1033-1037, (1974).
Koester, C., Scanning Mirror Microscope With Optical Sectioning Characteristics: Applications In Ophthalmology, Applied Optics, vol. 19, No. 11, pp. 1749-1757, Jun. 1980.
New, K.C., et al., In Vivo Imaging of Human Teeth and Skin Using Real-Time Confocal Microscopy, Scanning, vol. 13, 369-372 (1991).
Corcuff, P. et al., Morphometry of Human Epidermals In Vivo by Real-time Confocal microscopy, Arch Dermatol Res 285:475-481 (1993).
Rajadhyakasha et al., “In Vivo Cunfocal Scanning Laser Microscopy of Human Skin: Melanin Provides Strong Contrast”, The Journal of Investigative Dermatology vol. 104, No. 6, Jun. 1997.
Brumberg et al., “Hand-held contact microscope for medical examinations”, Soviet Journal of Optical Tehcnology, Jan. 1974, vol. 41, No. 1.
Delaney, P. et al., Fiber-optic laser scanning confocal microscope suitable for fluorescence Imaging, Applied Optics, vol. 33, No. 4, pp. 573-577 (1994).
Small Business Innovation Research Prog; Issued Sep. 28, 1992; Grant No. SSS-3 (BA) 1 R43 RRo7737-01; awarded by National Center for Research Resources; entitled Confocal Laser Scanning Microscope- Video, Vector & Zoom.
Delaney, P. et al., Fibre optic confocal imaging (FOCI) for subsurface microscopy of the colon in vivo, J. Anat. 184, 157-160 (1994).
Delaney, P. et al. Novel Microscopy Using Fibre Optic Confocal Imaging and its Suitability for Subsurface Blood Vessel Imaging In Vivo, Clinical and Experimental Pharmacology and Physiology, 20, 197-198 (1993).
Eastman Jay M.
Zavislan James M.
Farah A.
Lucid Inc.
Lukacher Kenneth J.
LandOfFree
Microscopic imaging apparatus and method does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Microscopic imaging apparatus and method, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Microscopic imaging apparatus and method will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3559962