Glucocorticoid mimetics, methods of making them,...

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

Reexamination Certificate

active

07553966

ABSTRACT:
Compounds of Formula (IA) and Formula (IB)wherein R1, R2, R3, R4, R5, and R6are as defined herein for Formula (IA) or Formula (IB), or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.

REFERENCES:
patent: 4880839 (1989-11-01), Tucker
patent: 5039691 (1991-08-01), Spagnuolo et al.
patent: 6323199 (2001-11-01), Lehmann et al.
patent: 6329534 (2001-12-01), Kym et al.
patent: 6380223 (2002-04-01), Dow et al.
patent: 6436986 (2002-08-01), Kym et al.
patent: 6506766 (2003-01-01), Coghlan et al.
patent: 6583180 (2003-06-01), Link et al.
patent: 6903215 (2005-06-01), Betageri et al.
patent: 2002/0156311 (2002-10-01), Link et al.
patent: 2005/0176706 (2005-08-01), Bekkali et al.
patent: 2006/0189647 (2006-08-01), Bekkali et al.
patent: 2007/0100142 (2007-05-01), Song et al.
patent: 900594 (1984-09-01), None
patent: 0 154 528 (1985-03-01), None
patent: 0 154 528 (1985-03-01), None
patent: 0 253 500 (1991-02-01), None
patent: 0 253 503 (1991-12-01), None
patent: 2 146 987 (1984-09-01), None
patent: WO 96/19458 (1996-06-01), None
patent: WO 97/27852 (1997-08-01), None
patent: WO 98/54159 (1998-12-01), None
patent: WO 99/41256 (1999-02-01), None
patent: WO 00/32584 (2000-06-01), None
patent: WO 00/66522 (2000-11-01), None
patent: WO 02/02565 (2002-01-01), None
patent: WO 02/10143 (2002-02-01), None
patent: WO 02064550 (2002-08-01), None
Hamann, Lawrence, et al ; Discovery of a potent, Orally active, Nonsteroidal Androgen Receptor Agonist: 4-Ethyl-1,2,3,4-tetrahydro-6-(trifluoromethyl)-8-pyridono[5,6-g]quinoline(LG12107I), J. Med Chem, 1999, 42, 210-212.
Pooley, Charlotte, et al; Discovery and Preliminary SAR Studies of a Novel Nonsteroidal Progesterone Receptor Antagonist Pharmacophore, J. Med. Chem 1998, 41, 3461-3466.
Edwards, James, P. et al; 5-Aryl-1,2-dihydro-5H-chromeno[3,4-f]quinolines as Potent, Orally Active, Nonsteroidal Progestgerone Receptor Agonists; The Effect of D-Ring Substituents, J. Med. Chem 1998. 41, 303-310.
Zhi, Lin, et al; 5-Aryl-1,2-dihydro-5H-chromeno[3,4-f]quinolines: A Novel Class of Nonsteroidal Human Progesterone Receptor Agonists, J. Med. Chem 1998, 41, 291-302.
Zhi, Lin; et al 5-Aryl-1,2,3,4-tetrahydrochromeno[3,4-f]quinolin-3-ones as a Novel Class Of Nonsteroidal Progesterone Receptor Agonists: Effect of A-Ring Modification, J. Med. Chem 1999, 42, 1466-1472.
Tegley, Christopher, et al; 5-Benzylidene 1,2-Dihydrochromeno[3,4-f]quinolines, A Novel Class of Nonsteroidal Human Progesterone Receptor Agonists; J. Med. Chem 1998, 41, 4354-4359.
Edwards, James, P. et al; Preparation, Resolution and Biological Evaluation of 5-Aryl-1,2-dihydro-5H-chromeno[3,4-f]quinolines as Potent, Orally Active, Nonsteroidal Progestgerone Receptor Agonists: J. Med. Chem. 1998, 41, 2779-2785.
Hamann, Lawrence, et al; Synthesis and Biological Activity of a Novel Series of Nonsteroidal, Peripherally Selective androgen Receptor Antagonists Derived from 1,2-Dihydropyridono[5,6-g]quinolines J. Med. Chem 1998, 41, 623-639.
English Translation of WO/02/10143, 2002.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Glucocorticoid mimetics, methods of making them,... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Glucocorticoid mimetics, methods of making them,..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Glucocorticoid mimetics, methods of making them,... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4132034

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.