Glucagon receptor antagonists, preparation and therapeutic uses

Details Glucagon receptor antagonists, preparation and therapeutic uses Glucagon receptor antagonists, preparation and therapeutic uses

2011-08-02

2011-08-02

Rao, Deepak (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C544S335000

Reexamination Certificate

active

07989457

ABSTRACT:
The present invention discloses novel compounds of Formula (I), or pharmaceutically acceptable salts thereof, which have glucagon receptor antagonist or inverse agonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula (I) as well as methods of using them to treat diabetic and other glucagon related metabolic disorders, and the like.

REFERENCES:
patent: 5811459 (1998-09-01), Breault et al.
patent: WO 03/048109 (2003-06-01), None
patent: WO 2004/002480 (2004-01-01), None
Kurukulasuriya, Ravi et al. “Biaryl amide glucagon receptor antagonists”Bioorganic & Medicinal Chemistry Letters,14(9), p. 2049; table 1; 2004.
Beasley, Helen L. et al. “Development of a Panel of Immunoassays for Monitory DDT, Its Metablolites, and Analogs in Food and Environmental Matrixes”Journal of Agricultural and Food Chemistry,46(8), pp. 3339-3352; compound Hapten VI, 1998.
Kundu, B. et al. “Identification of novel.alpha.-glucosidase inhibitors by screening libraries based on N-'r-(Benzyloxy) benzoyl! alanine derivatives”Chemical Abstratcts Service,5(7), pp. 545-550, 2002.

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