GLP-2 mimetibodies, polypeptides, compositions, methods and...

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 25 or more amino acid residues in defined sequence

Reexamination Certificate

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C530S350000, C530S387300, C514S012200

Reexamination Certificate

active

07812121

ABSTRACT:
Mammalian GLP-2 mimetibodies, polypeptides and nucleic acids are disclosed. Methods of utilizing the mimetibodies and polypeptides to treat GLP-2 related diseases are also disclosed.

REFERENCES:
patent: 5789379 (1998-08-01), Drucker et al.
patent: 7112567 (2006-09-01), Bridon et al.
patent: 2001/0021767 (2001-09-01), Drucker et al.
patent: 2007/0036806 (2007-02-01), Glaesner et al.
patent: WO 2005/097175 (2005-10-01), None
patent: WO2007/067828 (2007-06-01), None
Hartmann, et al., “Structure, measurement and secretion of human glucagon-like peptide-2,” Peptides, 21: 73-80 (2000).
Bjerknes, et al., “Modulation of specific intestinal epithelial progenitors by enteric neurons,” Proceedings of the National Academy of Science USA, 92(22): 12497-12502 (2001).
Orskov, et al., “CLP-2 stimulates colonic growth via KGF, released subepithelial myofibroblasts with GLP-2 receptors,” Science, 124: 105-112 (2004).
Bulut, et al., “Glucagon-like peptide 2 improves intestinal wound healing shown through induction of epithelial cell migration in vitro—evidence for a TFG-β-mediated effect,” Regulatory Peptides, 121: 137-143 (2004).
Kalff, et al., “Biphasic response to gut manipulation and temporal correlation of cellular infiltrates and muscle dysfunction in rat,” Surgery, 126: 498-509 (1999).
Wehner, et al., Induction of IL-6 within the rodent intestinal muscularis after intestinal surgical stress, Surgery, 137: 436-446 (2005).
Shibata, et al., “Effects of Prostaglandin F2α and Cisapride on Small Intestinal Activity During the Early Postoperative Period in Humans,” Surgery Today, 28: 787-791 (1998).
Viscusi, et al., “Alvimopan, a peripherally acting mu-opioid receptor antagonist, compared with placebo in postoperative ileus after major abdominal surgery,” Surgery Endoscopy, 20: 64-70 (2006).
Platell, et al., “The management of patients with the short bowel syndrome,” World Journal of Gastroenterology, 8(1): 13-20 (2002).
Holst, et al., “Glucagon-like Peptide 1 (GLP-1): An Intestinal Hormone, Signalling Nutritional Abundance, with an Unusual Therapeutic Potential,” Trends in Endocrinology and Metabolism, 10(6): 229-235 (1999).
Anup, et al., “Surgical Stress and the Gastrointestinal Tract,” Journal of Surgical Research, 92-291-300 (2000).
Bouras, et al., “Effect of cyclooxygenase-2 inhibitors on gastric emptying and small intestinal transmit in humans,” Neurogastroenterology Motil., 16: 729-735 (2004).
Drucker, et al., “Induction of intestinal epithelial proliferation by glucagon-like peptide 2,” Proceedings of the National Academy of Science USA, 93: 7911-7916 (1996).
Yusta, et al., “The Glucagon-like Peptide-2 Receptor Mediates Direct Inhibition of Cellular Apoptosis via A cAMP-dependent Protein Kinase-independent Pathway,” The Journal of Biological Chemistry, 275(45): 35345-35352 (2000).
Hartmann, et al., “In Vivo and in Vitro Degradation of Glucagon-Like Peptide-2 in Humans,” The Journal of Clinical Endocrinology & Metabolism, 85(8): 2884-2888 (2000).
Prasad, et al., “Glucagonlike Peptide-2 Analogue Enhances Intestinal Mucosal Mass After Ischemia and Reperfusion,” Journal of Pediatric Surgery, 35(2): 357-259 (2000).
Josephs, et al., “Products of Cyclooxygenase-2 Catalysis Regulate Postoperative Bowel Motility,” Journal of Surgical Research, 86: 50-54 (1999).
Brubaker, et al., “Minireview: Glucagon-Like Peptides Regulate Cell Proliferation and Apoptosis in the Pancreas, Gut, and Central Nervous System,” Endocrinology, 145(6): 2653-2659 (2004).
Holte, et al., “Postoperative ileus: a preventable event,” British Journal of Surgery, 97: 1480-1493 (2000).
Drucker, et al., “Glucagon-Like Peptide 2,” The Journal of Clinical Endocrinology & Metabolism, 86(4): 1759-1764 (2001).
von Ritter, et al., “Neutrophilic Proteases: Mediators of Formyl-Methionyl-Leucyl-Phenylalanine-Induced Ileitis in Rats,” Gastroenterology, 97: 605-609 (1989).
Troncone, et al., “Increased intestinal sugar permeability after challenge in children with cow's milk allergy or intolerance,” Allergy, 49: 142-146 (1994).
H.B. Mikkelsen, “Macrophages in the external muscle layers of mammalian intestines,” Histology and Histopathology, 10: 719-736 (1995).
Holte, et al., “Prevention of postoperative ileus,” Minerva Anestesiology, 68: 152-156 (2002).
Kouris, et al., “The effect of glucagon-like peptide 2 on intestinal permeability and bacterial translocation in acute necrotizing pancreatitis,” The American Journal of Surgery, 181: 571-575 (2001).
Holte, et al., “Postoperative ileus: a preventable event,” British Journal of Surgery, 87: 1480-1493 (2000).
Gonenne, et al., “Effect of Alvimopan and codeine on Gastrointestinal Transit: A Randomized Controlled Study,” Clinical Gastroenterology and Hepatology, 3: 784-791 (2005).
Shin, et al., “Glucagon-like peptide2: an update,” Current Opinion in Endocrinology & Diabetes, 12(1): 63-71 (2005).
Bauer, et al., “Ileus in critical illness: mechanisms and management,” Current Opinion in Critical Care, 8: 152-157 (2002).
Orskov, et al., “Carboxypeptidase-B-like processing of the C-terminus of glucagon-like peptide-2 in pig and human small intestine,” FEB, 247(20): 193-196 (1989).
Jeppesen, et al., “Glucagon-like Peptide 2 Improves Nutrient Absorption and Nutritional Status in Short-Bowel Patients with No Colon,” Gastroenterology, 120: 806-815 (2001).
Yusta, et al., “Enteroendocrine Localization of GLP-2 Receptor Expression in Humans and Rodents,” Gastroenterology, 119: 744-755 (2000).
Kalff, et al., “Role of Inducible Nitric Oxide Synthase in Postoperative Intestinal Smooth Muscle Dysfunction in Rodents,” Gastroenterology, 118: 316-327 (2000).
Schwarz, et al., “Prostanoid Production Via COX-2 as a Causative Mechanism of Rodent Postoperative Ileus,” Gastroenterology, 121: 1354-1371 (2001).
Guan, et al., “GLP-2 Receptor Localizes to Enteric Neurons and Endocrine Cells Expressing Vasoactive Peptides and Mediates Increased Blood Flow,” Gastroenterology, 130: 150-164 (2006).
Rubin, et al., “Nutrient Regulation of Intestinal Growth and Adaptation: Role of Glucagon-like Peptide 2 and the Enteroendocrine Cell,” Gastroenterology, 117: 261-263 (1999).
Benjamin, et al., “Glucagon-like peptide 2 enhances intestinal epithelial barrier function of both transcellular and paracellular pathways in the mouse,” Gut, 47(1): 112-119 (2000).
Kalff, et al., “Leukocytes of the intestinal muscularis: their phenotype and isolation,” Journal of Leukocyte Biology, 63: 683-691 (1998).
Damholt, et al., “Proglucagon Processing Profile in Canine L Cells Expressing Endogenous Prohormone Convertase 1/3 and Prohormone convertase 2,” Endocrinology, 140(10): 4800-4808 (1999).
Bielefedt, et al., “Intestinal Motility During Hypoxia and Reoxygenation in Vitro,” Digestive Diseases & Sciences, 42(5): 878-884 (1997).
Kalff, et al., “Surgical Manipulation of the Gut Elicits an Intestinal Muscularis Inflammatory Response Resulting in Postsurgical Ileus,” Annals of Surgery, 228(5): 652-663 (1998).
Turler, et al., “Colonic Postoperative Inflammatory Ileus in the Rat,” Annals of Surgery, 236(10): 56-66 (2002).
Brubaker, et al., “Circulating and Tissue Forms of the Intestinal Growth Factor, Glucagon-Like Peptide-2,” Endocrinology, 138(11): 4837-4843 (1997).
Kalff, et al., “Surgically Induced Leukocytic Infiltrates Within the Rate Intestinal Muscularis Mediate Postoperative Ileus,” Gastroenterology, 117: 378-387 (1999).
Livingston, et al., “Postoperative Ileus,” Digestive Diseases and Sciences, 35(1): 121-13

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