Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2005-04-26
2005-04-26
Nolan, Patrick J. (Department: 1644)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
Reexamination Certificate
active
06884579
ABSTRACT:
Since glucagon-like peptide-1 (GLP-1) is the most potent insulinotropic hormone known and has been shown to stimulate insulin secretion strongly in patients with type II diabetes, this invention uses GLP-1 or its biologically active analogues in β-cell stimulatory tests in order to test β-cell function in a simple way. The test provides information about insulin secretory capacity, is easy and reproducible and has insignificant side effects.
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patent: WO 9964061 (1999-12-01), None
Vilsboll, Tina et al., “Evaluation of .beta.-cell secretory capacity using glucagon-like peptide”, Diabetes Care (2000), 23(6), 807-812; Database from Chemlabs Online X0002156250.
Hiroyoshi, M. et al., “Elevated plasma levels of glucagon-like peptide-! after oral glucose ingestion in patients with pancreatic diabetes”, Am. J. Gastroenterol, (1999), 94(4), 976-981; Database from Chemlabs Online X0002156251.
Byrne, Maria, M. et al., “Glucagon-like peptide 1 improves the ability of the .beta.-cell to sense and respond to glucose in subjects with impaired glucose tolerance”, Diabetes (1998), 47(8), 1259-1265; Database from Chemlabs Online XP002156252.
Dachicourt, N. et al., “Glucagon-like peptide-1 (7-36)-amide confers glucose sensitivity to previously glucose-incompetent.beta.-cells in diabetic rats: In vivo and in vitro studies”, J. Endoctrinol, (1997) 155(2), 369-376; Database from Chemlabs Online XP002156253.
Holst Jens J.
Vilsboll Tina
Amylin Pharmaceuticals Inc.
Arnold & Porter LLP
Holman Molly A.
Nolan Patrick J.
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