Genetically engineered polypeptides with determinants of the hum

Details Genetically engineered polypeptides with determinants of the hum Genetically engineered polypeptides with determinants of the hum

1989-01-27

1991-10-01

Nucker, Christine

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

530326, 530324, 530828, 530836, 4351723, 435 691, 435 693, 935 9, 935 10, 935 38, 935 55, C07K 700

Patent

active

050534890

ABSTRACT:
A carbohydrate-free polypeptide coded for by a human DNA sequence of 309 nucleotides is immunologically reactive with monoclonal antibody against the human DF3 breast carcinoma-associated antigen. The nucleotide sequence is also useful as a probe to reveal restriction fragment length polymorphisms in human DNA.

REFERENCES:
S. Gendler et al, J. Biol. Chem., vol. 263, pp. 12820-12823 (Sep. 15, 1988 issue).
D. M. Swallow et al, Nature, vol. 327, 82-84 (1987).
S. J. Gendler et al, Proc. Natl. Acad. Sci., U.S.A., vol. 84, 6060 (1987).
S. J. Gendler et al, Abstract A-11, Biennial Intl. Breast Cancer Res. Conf., Miami (Mar. 1-5, 1987).
J. Siddiqui et al, Proc. Natl. Acad. Sci. (U.S.A.) vol. 85, pp. 2320-2323 (Apr. 1988).
Sekine et al, Journal of Immunology, vol. 135, No. 5, Nov. 1985, "Purification and Characterization of a High Molecular Weight Glycoprotein Detectable in Human Milk and Breast Carcinomas", pp. 3610-3615.

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