Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1995-08-24
1999-03-16
Patterson, Jr., Charles L.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
435190, C12N 1553
Patent
active
058832408
ABSTRACT:
The present invention relates generally to a nucleic acid molecule encoding, or complementary to a nucleic acid molecule encoding, a recombinant NAD+ dependent glucocorticoid dehydrogenase and more particularly to 11 .beta.-hydroxysteroid dehydrogenase-2 (11 .beta.HSD2). When expressed in a prokaryotic or eukaryotic cell, the nucleic acid molecule of the present invention is used to assay for potential agonists or antagonist of glucocorticoid dehydrogenase activity. Further, the present invention relates to inmmunoreactive molecules to NAD+ dependent glucocorticold dehydrogenase which provide the basis for a new range of diagnostic agents for use, such as in the diagnosis and treatment of hypertension and in predicting the potential outcome of in vitro fertilization and embryo transfer procedures.
REFERENCES:
Michael, A.E. et al., The Lancet, 342: 711-12 (1993) (Exhibit 2).
Agarwal, A.K. et al., J. Bio. Chem., 269: 25959-62 (1994) (Exhibit 3).
Albiston et al. (Nov. 1994) Mol. Cell. Endocrin. 105: R11-R17. "Cloning and tissue distribution of the human 11.beta.-hydroxysteroid dehydrogenas type z enzyme" .
Hillier et al. (Feb. 1995), Wash-U-Merck EST project, accession T52701, T52702.
Wv et al. (1993) J. Biol Chem 2 68:12964-12969 "Expression cloning and characterization of human 17.beta.-hydroxysteriod dehydrogenase ...".
Albiston Anthony L.
Funder John W.
Krozowski Zygmunt S.
Obeyesekere Varuni R.
Smith Robin E.
Baker Medical Research Institute
Patterson Jr. Charles L.
White John P.
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