Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – Molecular bilayer structure
Patent
1978-07-14
1981-01-06
Padgett, Benjamin R.
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
Molecular bilayer structure
128653, 128654, 128659, 424 15, 424 9, A61K 4900, A61K 4300, G01T 100
Patent
active
042436524
ABSTRACT:
Technetium-99m has ideal characteristics for imaging the upper and lower GI tract and determining stomach emptying and intestinal transit time when used with an insoluble particulate material. For example, crystalline and amorphous calcium phosphate particles can be effectively labeled in a one-step process using .sup.99m TcO.sub.4 and SnCl.sub.2. These labeled particles have insignificant mass and when administered orally pass through the GI tract unchanged, without affecting the handling and density of the intestinal contents. Visualization of the esophageal entry into the stomach, the greater and lesser curvatures of the stomach, ejection into the duodenum, and rates of passage through the upper and lower GI tract are obtained. The slurry of .sup.99m Tc particulate can be given rectally by enema. Good images of the cecum and the ascending, transverse, and descending colon are obtained. Mucosa folds and the splenic and hepatic flexures are visualized. The resilience of the large intestine is also readily visualized by pneumocolonographic techniques.
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Chaudhuri et al., J. Nucl. Med., vol. 15, 1974, p. 483.
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Heading et al., Gastroenterology, vol. 71, 1976, pp. 45-50.
Thomas et al., J. Nucl. Med., vol. 18, 1977, pp. 896-897.
Rezai-Zadeh et al., J. Nucl. Med., vol. 18, 1977, p. 635.
Theodorakis et al., J. Nucl. Med., vol. 16, 1975, p. 575.
Goldstein Steven J.
Nucker Christine M.
Padgett Benjamin R.
The Procter & Gamble & Company
Witte Richard C.
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