Gastrin releasing peptide-like peptides

Details Gastrin releasing peptide-like peptides Gastrin releasing peptide-like peptides

1984-04-19

1986-09-23

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 15, 530326, A61K 1743, C07K 706, C07K 708

Patent

active

046135863

ABSTRACT:
Novel peptides having gastrin releasing peptide-like activity having the structures Ala-Pro-Val-Ser-Val-Gly-Gly-Gly-Thr-Val-Leu-Ala-Lys-Met-Tyr-Pro-NH.sub.2 and Gly-Asn-His-Trp-Ala-Val-Gly-His-Leu-Met-NH.sub.2, have been isolated from rat and guinea pig brain extracts and synthesized by a solid phase peptide synthesis methods. The GRP-like peptides are useful as pharmaceuticals to lower body temperature, increase respiratory activity, reduce food intake, stimulate pancreatic hormone release, stimulate pituitary hormone release and suppress thyroid hormone release in mammals.

REFERENCES:
patent: 4207311 (1980-06-01), Brown et al.
patent: 4331661 (1982-05-01), Marki et al.
Biochem. and Biophys. Res. Commun. vol. 90, No. 1, (1979) 227-233, McDonald, et al..
Biochem. and Biophys. Res. Commun. vol. 112, No. 2, (1983) 528-536.

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