Ganglioside ceramidase and process for producing same

Details Ganglioside ceramidase and process for producing same Ganglioside ceramidase and process for producing same

1990-09-12

1992-09-01

Brown, Johnnie H.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

435183, 435101, 435 681, 435872, 536 11, 536119, 536 53, C12N 978, C12N 900

Patent

active

051438410

ABSTRACT:
This invention provides a novel ganglioside ceramidase which has a substrate specificity at least for GD1a, GM1, GM2 and GM3 and acts at least on GD1a, GM1, GM2 and GM3 and catalyzes the reaction of hydrolysis of ganglioside to lysoganglioside and fatty acid.
This invention further provides a process for producing the novel ganglioside ceramidase which comprises cultivating ganglioside ceramidase producing strain belonging to the genus Nocardia in a culture medium and collecting ganglioside ceramidase from the culture.

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