Gamma-pyrone-3-acetic acid as an inhibitor or interleukin-1 .bet

Details Gamma-pyrone-3-acetic acid as an inhibitor or interleukin-1 .bet Gamma-pyrone-3-acetic acid as an inhibitor or interleukin-1 .bet

1993-05-17

1995-05-02

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

549420, A61K 3135

Patent

active

054119855

ABSTRACT:
Novel peptidyl derivatives of formula I are found to be potent inhibitors of interleukin-1.beta. converting enzyme (ICE). Compounds of formula I may be useful in the treatment of inflammatory or immune-based diseases of the lung and airways; central nervous system and surrounding membranes; the eyes and ears; joints, bones, and connective tissues; cardiovascular system including the pericardium; the gastrointestinal and urogenital systems; the skin and mucosal membranes. Compounds of formula I are also useful in treating the complications of infection (e.g., gram negative shock) and tumors in which IL 1 functions as an autocrine growth factor or as a mediator of cachexia. ##STR1##

REFERENCES:
patent: 4603144 (1986-07-01), Campbell et al.
Engel, et al., Helv. Chim. Acta 32 pp. 1752-1758 (1949).
Mycofaxon (46) pp. 141-154 (1993) A Synoptic Key to Xylaria Species from Continental United States and Canada Based on Cultural and Anamorphic Features.

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