Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Cyclic peptides
Patent
1994-03-11
1997-06-03
Jacobson, Dian C.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
Cyclic peptides
530321, 530324, 530827, 530830, C07K 14435, C07K 14465, A61K 3817
Patent
active
056355947
ABSTRACT:
Peptide-based compounds containing six invariant cysteine residues are useful as preservatives and in preventing, treating, or ameliorating microbial infection in animals and plants. These compounds are of the formulas: ##STR1## wherein each B.sub.i is a basic amino acid and the N-terminal acylated and/or C-terminal amidated or esterified forms thereof, either in optionally --SH stabilized linear or in cystine-bridged form.
REFERENCES:
patent: 4543252 (1985-09-01), Lehrer et al.
patent: 4659692 (1987-04-01), Lehrer et al.
patent: 4705777 (1987-11-01), Lehrer et al.
Evans, E.W. et al. J. Leukocyte Biology 56:661-665 (1994).
Nakamura et al., Tachyplesin, a Class of Antimicorbial Peptide from the Hemocytes of the Horshoe Crab (Tachupleus tridentatus), J. Biol. Chem. (1988) 263:16709-16713.
Miyata et al., Antimicrobial Peptides, Isolated from Horseshoe Crab Hemocytes, Tachyplesin II, and Polyphemusins I and II: Chemical Structures and Biological Activity, J. Biochem; (1989) 106:663-668.
Murakami et al., Direct Virus Inactivation of Tachyplesin I and Its Isopeptides from Horseshoe Crab Hemocytes, Chemotherapy (1991) 37:327-334.
Morimoto et al., Inhibitory Effect of Tachyplesin I on the Proliferation of Human Immunodeficiency Virus in vitro, Chemotherapy (1991) 37:206-211.
Nakashima et al., Anti-Human Immunodeficiency Virus of a Novel Synthetic Peptide, T22 ([Tyr-5,12, Lys-7]Polyphemusin II): a Possible Inhibitor of Virus-Cell Fusion, Antimicrobial Agents and Chemotherapy (1992) 1249-1255.
Lehrer et al., Direct Inactivation of Viruses by MCP-1 an MCP-2 Natural Peptide Antibiotics from Rabbit Leukocytes; J. Virol. (1985) 54:467-472.
Kokryakov et al., Protegrins: leukocyte antimicrobial peptides that combine features of corticostatic defensins adn tachyplesins; FEBS (1993) 337:231-236.
Mirgorodskaya, et al., Primary structure of three cationic peptides from porcine neutrophils; FEBS (1993) 330:339-342.
Storici, et al., A Novel cDNA Sequence Encoding a Pih Leukocyte Antimicrobial Peptide with a Cathelin-like Pro-sequence; Biochem. Biophys. Res. Comm. (1993) 196:1363-1367.
Lehrer, R.I. et al., Defensins: Endogenous Antibiotic Peptides of Animal Cells, Cell (1991) 64:229-230.
Lehrer, R.I. et al., Defensins: Antimicrobial and Cytotoxic Peptides of Mammalian Cells, Ann Rev Immunol (1993) 11:105-128.
Selsted, M.E. et al., Purification, Primary Structures, and Antibacterial Activities of .beta.-Defensins, a New Family of Antimicrobial Peptides from Bovine Neutrophils; J Biol Chem (1993) 268:6641-6648.
Tang, Y-Q., Characterization of the Disulfide Motif in BNBD-12, an Antimicrobial .beta.-Defensin Peptide from Bovine Neutrophils; J Biol Chem (1993) 268:6649-6653.
Diamond, G. et al., Tracheal antimicrobial peptide, a cysteine-rich peptide from mammalian tracheal mucosa: Peptide isolation and cloning of a cDNA; Proc Natl Acad Sci (USA) (1991) 88:3952-3958.
Diamond, G. et al., Airway epithelial cells are the site of expression of a mammalian antimicrobial peptide gene; Proc Natl Acad Sci USA (1993) 90:4596-4600.
Lambert et al., Insect Immunity: Isolation from immune blood of the dipteran Phormia terranovae of two insect antibacterial peptides with sequence homology to rabbit lung macrophage bactericidal peptides, Proc. Natl. Acad. Sci. (USA) (1989) 88:262-265.
Broekaert et al., Antimicrobial Peptides from Amaranthus caudatus Seeds with Sequence Homology tothe Cysteine/Glycine-Rich Domain o Chitin-Binding Proteins, Biochemistry (1992) 31:4308-4314.
Cornelissen et al., Strategies for Control of Fungal Disease with Transgenic Plants, Plant Physiol (1993) 101:709-712.
Haln et al., Disease resistance results from foreign phytoalexin expression in a novel plant, Nature (1993) 361:153-156.
Harwig Sylvia S. L.
Kokryakov Vladimir N.
Lehrer Robert I.
Jacobson Dian C.
University of California, Los Angeles
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