Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Reexamination Certificate
2008-06-02
2010-10-05
Mertz, Prema (Department: 1646)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
C435S069500, C435S071100
Reexamination Certificate
active
07807413
ABSTRACT:
A method is provided for introducing a GAG binding site into a protein comprising the steps:identifying a region in a protein which is not essential for structure maintenanceintroducing at least one basic amino acid into said site and/or deleting at least one bulky and/or acidic amino acid in said site,whereby said GAG binding site has a GAG binding affinity of Kd≦10 μM, preferably ≦1 μM, still preferred ≦0.1 μM, as well as modified GAG binding proteins.
REFERENCES:
patent: WO 92/07935 (1992-05-01), None
patent: WO 96/34965 (1996-11-01), None
patent: WO 02/20715 (2002-03-01), None
Brander, Translation of Klonierung, Expression und Reinigung bindungsmodifizierter Interleukin-8 Mutanten, Zur Erlangung des akademischen Grades einer, Magistra Pharmaciae, an der Naturwissenschaftlichen Fakultät der, Karl-Franzens-Universität Graz (2002).
Brandner, Klonierung, Expression und Reinigung bindungsmodifizierter Interleukin-8 Mutanten, Zur Erlangung des akademischen Grades einer, Magistra Pharmaciae, an der Naturwissenschaftlichen Fakultät der, Karl-Franzens-Universität Graz (2002) (with English Abstract).
Butcher et al., FEBS Letters 409: 183-187 (1997).
Ecker, Österreichische Apotheker-Zeitung 57(14): 658-660 (2003).
Jayaraman et al., FEBS Letters 482: 154-158 (2000).
Jinno-Oue et al., Journal of Virology 75(24): 12439-12445 (2001).
Hileman et al., BioEssays 20: 156-167 (1998).
Lortat-Jacob et al., PNAS 99(3): 1229-1234 (2002).
Verrecchio et al., The Journal of Biological Chemistry 275(11): 7701-7707 (2000).
Wong et al., The Journal of Biological Chemistry 273(29): 18617-18622 (1998).
Yang et al., Journal of Cellular Biochemistry 56: 455-468 (1994).
Mertz Prema
Perkins Coie LLP
Protaffin Biotechnologie AG
LandOfFree
GAG binding protein does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with GAG binding protein, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and GAG binding protein will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4227026