GABA and L-glutamic acid analogs for antiseizure treatment

Details GABA and L-glutamic acid analogs for antiseizure treatment GABA and L-glutamic acid analogs for antiseizure treatment

1995-04-12

1996-10-08

Shippen, Michael L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Radical -xh acid, or anhydride, acid halide or salt thereof...

514567, 514568, 562443, 562507, 562553, 562571, A61K 31195

Patent

active

055631754

ABSTRACT:
A compound of the formula ##STR1## wherein R.sub.1 is a straight or branched alkyl group having from 1 to 6 carbon atoms, phenyl, or cycloalkyl having from 3 to 6 carbon atoms; R.sub.2 is hydrogen or methyl; and R.sub.3 is hydrogen, methyl or carboxyl; which is useful in the treatment of seizure disorders. Processes are disclosed for the preparation of the compound. Intermediates prepared during the synthesis of the compound are also disclosed.

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Carson, J. Org. Chem., 20, pp. 1591-1601 (1955).
Colonge, Bull. Soc. Chim. Fr., pp. 598-603 (1962).
Andruszkiewicz, Synthesis, pp. 953-955.

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