G-rich polynucleotides for the treatment of Huntington's...

Details G-rich polynucleotides for the treatment of Huntington's... G-rich polynucleotides for the treatment of Huntington's...

2006-10-06

2010-10-05

Long, Scott (Department: 1633)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C536S063000

Reexamination Certificate

active

07807648

ABSTRACT:
The present invention relates to oligonucleotide compositions and therapeutic uses thereof to modify protein-protein interactions. In particular, the invention relates to the use of a guanidine-rich oligonucleotides to disrupt disease-causing protein aggregates, for example, Huntington's Disease (HD) protein aggregates.

REFERENCES:
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Bates, Paula J., et al. “Antiproliferative Activity of G-rich Oligonucleotides Correlates with Protein Binding”; The Journal of Biological Chemistry; vol. 274, No. 37, Sep. 10, 1999; pp. 26369-26377.
Dapic, V., et al. Antiproliferative Activity of G-Quartet-Forming Oligonucleotides with Backbone and Sugar Modifications; Biochemistry 2002, 41; pp. 3676-3685.
Xu, X., et al., “Inhibition of DNA Replication and Induction of S Phase Cell Cycle Arrest by G-rich Oligonucleotides”; The Journal of Biological Chemistry; vol. 276, No. 46, Nov. 16, 2001; pp. 43221-43230.

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