G proteins, polynucleotide encoding the same and utilization...

Details G proteins, polynucleotide encoding the same and utilization... G proteins, polynucleotide encoding the same and utilization...

2008-05-13

2008-05-13

Ulm, John (Department: 1649)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

C435S007100, C435S007200, C435S252300, C435S320100, C530S350000, C536S023500

Reexamination Certificate

active

07371541

ABSTRACT:
We identified a novel protein (Gm1) comprising an amino acid sequence part having a high homology with a domain having a high homology with a GTP binding site and a GTPase site conserved among G protein α subunits and a trimer forming domain conserved among G protein α subunits. The Gm1 is involved in an signal transduction via a G protein-coupled receptor (GPCR) stimulation. Accordingly, this protein is considered to be a novel G protein. The Gm1 is expressed intensively in human brain, thymus, testes, spleen, small intestine, uterus and heart. We also established a method for screening for a substance capable of regulating a cellular signal transduction employing a polynucleotide encoding the Gm1.

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