G-lactam derivatives as prostaglandin agonists

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C514S424000, C548S517000, C548S518000, C548S527000, C548S543000

Reexamination Certificate

active

10547676

ABSTRACT:
A gamma-lactam diene of Formula I:which is particularly useful as a medicament for the treatment of various disorders such as asthma, hypertension, osteoporosis, sexual dysfunction and fertility disorders.

REFERENCES:
patent: 6235780 (2001-05-01), Ohuchida et al.
patent: 2001/0056060 (2001-12-01), Cameron et al.
patent: 2002/0004495 (2002-01-01), Harada et al.
patent: 1 114 816 (2001-07-01), None
patent: 88/07537 (1988-10-01), None
patent: 99/02164 (1999-01-01), None
patent: 99/33794 (1999-07-01), None
patent: 00/03980 (2000-01-01), None
patent: 01/46140 (2001-06-01), None
patent: 02/24647 (2002-03-01), None
patent: 02/42268 (2002-05-01), None
patent: 03/007941 (2003-01-01), None
patent: 03/008377 (2003-01-01), None
Sato et al, Tetrahedron Letters, 1997, 38(22), pp. 3931-3934.
Katz et al, Prostaglandins—Basic and Clinical Considerations, May 1974, Anesthesiology, vol. 40, No. 5, pp. 471-475.
Buckley et al, Immunde Deficiency Foundation Diagnostic and Clinical Care Guidelines, article retrieved from Internet on Mar. 1, 2007,<< http://www.primaryimmune.org/pubs/book—diag/IDF%20Diagnostic%20and%20Clinical%20Care%20Guidelines%20-%20Final.pdf>>.
Andersson et al, The pharmacological treatment of urinary incontinence, BJU International, 1999, vol. 84, pp. 923-947.
Abramovitz et al. “The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs”, Biochimica et Biophysica Acta, vol. 1483, pp. 285-293 2000.
Benoit et al. “Latest discoveries in prostaglandin receptor modulators”, Expert Opin. Ther. Patents, vol. 12, No. 8, pp. 1225-1235 2002.
Choung et al. “Role of EP2 Receptors and cAMP in Prostaglandin E2 Regulated Expression of Type I Collagen alpha1, Lysyl Oxidase, and Cyclooxygenase-1 Genes in Human Embryo Lung Fibroblasts”, Journal of Cellular Biochemistry, vol. 71, pp. 254-263 1998.
Coleman et al. “Prostanoids and their Receptors”, In Comprehensive Medicinal Chemistry, The rational Design, Mechanistic Study and Therapeutic Application of Chemical Compounds, vol. 3, pp. 643-714 1989.
Coleman et al. “VIII. International Union of Pharmacology Classification of Prostanoid Receptors: Properties, Distribution, and Structure of the Receptors and Their Subtypes”, Pharmacological Reviews, vol. 46, No. 2, pp. 205-229 1994.
Fleisch et al. “LY171883, 1-<2-Hydroxy-3-Propyl-4-<4-(1H-Tetrazol-5-yl)Butoxy>Phenyl>Ethanone, an Orally Active Leukotriene D4 Antagonist”, The Journal of Pharmacology and Experimental Therapeutics, vol. 233, No. 1, pp. 148-157 1985.
Guth et al. “Topical Aspirin Plus HCI Gastric Lesions in the Rat”, Gastroenterology, vol. 76, No. 1, pp. 88-93 1979.
Hundertmark et al. “Pd(PhCN)2C12/P(t-Bu)3: A Versatile Catalyst for Sonogashira Reactions of Aryl Bromides at Room Temperature”, Organic Letters, vol. 2, No. 12, pp. 1729-1731 2000.
Langlois et al. “Intramolecular Mitsunobu reaction in the regio- and stereoselective synthesis of cis-4,5-disubstituted piperidin-2-ones”, Tetrahedron Letters, vol. 41, pp. 8285-8288, 2000.
Levi et al. “Regulation of prostanoid synthesis in microglial cells and effects of prostaglandin E2 on microglial functions”, Biochimie, vol. 80. pp. 899-904 1998.
Miyaura. “Nippon Yakurigaku Zasshi”, Folia Pharmacol. Jpn., vol. 117, pp. 293-297, with English abstract 2001.
Nair et al. “Folate Analogues. 31. Synthesis of the Reduced Derivatives of 11-Deazahomofolic Acid, 10-Methyl-11-deazahomofolic Acid, and Their Evaluation as Inhibitors of Glycinamide Ribonucleotide Formyltransferase”, J. Med Chem., vol. 32, pp. 1277-1283 1989.
Negishi et al. “A Selective Synthesis of (E)-2-Methyl-1-alkenyl lodides via Zirconium-Catalyzed Carboalumination”, Synthesis, pp. 501, 502, 1035, 1979.
Shen et al. “The Stille Reaction of 1,1-Dibromo-1-alkenes; Preparation of Trisubstituted Alkenes and Internal Alkynes”, J. Org. Chem., vol. 64, pp. 8873-8879 1999.
Baldwin et al. “(L)-Pyroglutamic Acid as a Chiral Starting Material For Asymmetric Synthesis”, Tetrahedron Letters, vol. 32, No. 10, pp. 1379-1380 1991.
Uenishi et al. “Stereoselective Hydrogenolysis of 1,1-Dibromo-1-alkenes and Stereospecific Synthesis of Conjugated (Z)-Alkenyl Compounds”, J. Org. Chem., vol. 63, pp. 8965-8975 1998.
Ushikubi et al. “Roles of Prostanoids Revealed from Studies Using Mice Lacking Specific Prostanoid Receptors”, Jpn. J. Pharmacol., vol. 83, pp. 279-285 2000.
Watanabe et al. “Total Synthesis of (±)-Dihydropinidine, (±)-Monomorine I, and (±)-Indolizidine 223AB (Gephyrotoxin 223AB) by Intramolecular Nitroso Diels-Alder Reaction”, J. Org. Chem., vol. 54, pp. 4088-4097 1989.

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