G-CSF receptor agonists

Details G-CSF receptor agonists G-CSF receptor agonists

1997-04-04

2000-08-08

Mertz, Prema

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435 711, 435 712, 435 912, 435 9141, 435325, 4352523, 4353201, 435471, 536 231, 536 235, 530351, C12N 1527, C12N 1563, C07K 14535

Patent

active

061000701

ABSTRACT:
Disclosed are novel G-CSF receptor agonist proteins, DNAs which encode the multi-functional hematopoietic receptor agonists proteins, methods of making the multi-functional hematopoietic receptor agonists proteins and methods of using the multi-functional hematopoietic receptor agonists proteins.

REFERENCES:
patent: 4810643 (1989-03-01), Souza et al.
patent: 4999291 (1991-03-01), Sousa
patent: 5399345 (1995-03-01), Schumacher et al.
patent: 5635599 (1997-06-01), Pastan et al.
Reeke et al, "Three-Dimensional Structure of Favin: Saccharide Binding-Cyclic Permutation in Leguminous Lectins", Science, Nov. 28, 1986, vol. 234 pp. 1108-1111.
Luger et al, "An 8-fold Ba Barrel Protein with Redundant Folding Possibilities", Protein Engineering, vol. 3 pp. 249-258.
Cunningham et al, "Favion versus concanavalin A: Circularly permuted amino acid sequences", Proc. Natl. Acad. Sci. USA, July 1979, vol. 76, No. 7, pp. 3218-3222.
Protasova et al, Circularly permuted dihydrofolate reductase of E.coli has functional activity and a destabilized tertiary structure:, Protein Engineering, 1994, vol. 7, No. 11, pp. 1373-1777.
Zhang et al, "Circular Permutation of T4 Lysozyme", Biochemistry, vol. 32, No. 46, 1993.
Luger et al, "Correct Folding of Circularly Permuted Variants of a Ba Barrel Enzyme in Vivo", Science, vol. 243.
Hahn et al, "Native-like in vivo folding of a circularly permuted jellyroll protein shown by crystal structure analysis", Proc. Natl. Acad. Sci. USA, 1994, vol. 91, pp. 10417-10421.
Lin et al, "Rearranging the domains of pepsinogen", Protein Science, 1995, vol. 4, pp. 159-166.
Yang et al, "Aspartate transcarbamoylase containing circularly permuted catalytic polypeptide chains", Proc. Natl. Acad. Sci. USA, 1993, vol. 90, pp. 11980-11984.
Vignai et al, "Circular permutation within the coenzyme binding domain of the tetrameric glyceraldehyde-3-phosphate dehydrogenase from Bacillus stearothermophilus", Protein Science, 1995, vol. 4., pp. 994-1000.
Goldenberg et al, "Circular and Circularly Permuted Forms of Bovine Pancreatic Trypsin Inhibitor", J. Mol. Biol. 1983, vol. 165, pp. 407-413.
Hemperly et al, "Circular permutation of amino acid sequences among legume lectins", TIBS, 1983, pp. 100-102.
Kreitman et al, "Circularly permuted interleukin 4 retains proliferative and binding activity", Cytokine, 1995, vol. 7, No. 4, pp. 311-318.
Li et al, "Degradation of Ornithine Decarboxylase", Mol. and Cel. Biol. 1993, vol. 13, No. 4, pp. 2377-2383.
Ritco et al, "Is the Continuity of the Domains Required for the Correct Folding of a Two-Domain Protein?", Biochemistry, 1995, vol. 34, pp. 16543-16551.
Garrett et al, "Are turns required for the folding of ribonuclease T1?", Protein Science, 1996, vol. 5., pp. 204-211.
Komar et al, "Kinetics of translation" FEBS Letters, 1995 vol. 376, pp. 195-198.
MacGregor et al, "A circularly permuted a-amylase-type", FEBS Letters, 1996, vol. 378, pp. 263-266.
Koebnik et al, "Membrane Assembly of Circulary Permuted Variants", JMB, 1995, vol. 250, pp. 617-626.
Buchwalder et al, "A fully active variant of Dihydrofolate Reductase with a circularly permuted sequence", Biochemistry, 1992, vol. 31, pp. 1621-1630.
Viguera et al, "The order of secondary structure elements", J. Mol. Biol, 1995, vol. 247, pp. 670-681.
Mullins et al. "Transposition of Protein Sequences: Circular Permutation of Ribonuclease T1", J. Am. Chem. Soc., 1994, vol. 116, pp. 5529-5533.
Horlick et al, "Permuteins of interleukin 1B--a simplified approach for the construction of permutated proteins having new termini", Protein Engineering, USA, 1992, vol. 5, pp. 427-431.
Kreitman et al, "A circularly permuted recombinant interleukin 4 toxin with increase activity", Proc. Natl. Acad. Sci. USA, 1993, vol. 91, pp. 6889-3893.
Watanabe et al, "Mutant Protein of Recombinant Human Granulocyte Colony-Stimulating Factor . . . ", Analytical Biochemistry, 1991, vol. 195 pp. 38-44.
Cunningham et al. Science, vol. 244, pp. 1081-1085, Jun. 1989.
George et al. in Macromolecular Sequencing & Synthesis, Ch. 12, pp. 127-149, 1988.

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