Fusion polypeptides, vaccines and compositions of FKBP...

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues

Reexamination Certificate

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Reexamination Certificate

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10179038

ABSTRACT:
The present invention relates to the cloning and expression of foreign protein or polypeptides in bacteria, such asEscherichia coli.In particular, this invention relates to expression tools comprising a FKBP-type peptidyl prolyl isomerase selected from the group consisting of FkpA, SlyD, and trigger factor; methods of recombinant protein expression, the recombinant polypeptides thus obtained, as well as to the use of such polypeptides.

REFERENCES:
patent: 5908626 (1999-06-01), Chang et al.
patent: 6153377 (2000-11-01), Devare et al.
patent: 6207420 (2001-03-01), Harrison et al.
patent: 6248329 (2001-06-01), Chandrashekar et al.
patent: 0 293 249 (1992-08-01), None
patent: WO 93/25533 (1993-12-01), None
patent: WO 98/01349 (1998-01-01), None
patent: WO 98/13496 (1998-01-01), None
patent: WO 00 20606 (2000-04-01), None
patent: WO 00/28011 (2000-05-01), None
(The Dictionary of Immunology, Herbert et al eds, Academic Press, 1995).
Feng et al (Infection and Immunity, 64(1):363-365, 1996).
Ellis, R.W. (Chapter 29 of “VACCINES” Plotkin, S.A. et al. (eds) published by W. B. Saunders company (Philadelphia) in 1988, especially p. 571.
Kohda et al, Biochemical Engineering Journal, 10:39-45, 2002; see abstract and discussion.
Weir et al Handbook of Experimental Immunology, vol. 1:Immunochemistry, p. 8.14-8.15.
Riffkin et al., Gene, 167:279-283, 1995.
Abaza et al. ,J. of Protein Chemistry, 11(5):433-444, 1992.
Paul, Fundamental Immunology (Philadelphis & New York, Lippincott-Raven Publishers, 1993) pp. 250 and 1311-1312.
Cruse et al. Illustrated Dictionary of Immunology (Boca Raton, FL, CRC Press, Inc. 1995) p. 309.
Cohen et al, PNAS 96(1.
Attwood (Science, 290:471-473, 2000).
Beaucage., S.L., et al.,Deoxynucleoside Phosphoramidites—A New Class of Key Intermediates for Deoxypolynucleotide Synthesis, Department of Chemistry, University of Colorado, pp. 1859-1862.
Fischer, G.,Cyclophilin and Peptidyl-Prolyl Cis-Trans Isomerase are Probably Identical Proteins, NATURE, vol. 337 Feb. 2, 1989.
Hottenrott, S., et al.,The Escherichia coli SlyD is a Metal Ion-Regulated Peptidyl-Prolyl Cis/Trans-Isomerase, The Journal of Biological Chemistry, vol. 272, No. 25, Issue of Jun. 20, pp. 15697-15701, 1997.
Kapust, R.B., et al.,Escherichia coli Maltose-Binding Protein is Uncommonly Effective at Promoting the Solubility of Polypeptides to Which it is Fused, Protein Science (1999), pp. 1668-1674.
Kay, J.E.,Structure-Function Relationships in the FK506-Binding Proteing (FKBP) Family of Peptidylprolyl Cis-Trans Isomerases, BIOCHEM. J., (1996), 314, 361-385.
Lane, W.S.,Complete Amino Acid Sequence of the FK506 and Rapamycin Binding Protein, FKBP, Isolated from Calf Thymus, Journal of Protein Chemistry, pp. 151-160, vol. 10, No. 2, 1991.
Maniatis, T., et al.,Molecular Cloning, A Laboratory Manual, Cold Spring Harbor Laboratory, 1982, Table of Contents, Seven Pages, only table of contents.
Matteucci, M.D., et al.,Synthesis of Deoxyoligonucleotides on a Polymer Support, Journal of The American Chemical Society, vol. 103, No. 11, 1981.
Metzger D., et al.,The Human Oestrogen Receptor Functions in Yeast, NATURE, pp. 31-316, vol. 334, Jul. 7, 1988.
Rahfeld, J., et al.,Confirmation of the Existence of a Third Family Among Peptidyl-Prolyl Cisltrans Isomerases Amino Acid Sequence and Recombinant Production of Parvulin, FEBS Letters, 352 (1994) pp. 180-184.
Ramm, K., et al.,The Periplasmic Escherichia coli Peptidylprolyl Cis, Trans-Isomerase FkpA, The Journal of Biological Chemistry, vol. 275, No. 22, Issue of Jun. 2, pp. 17106-17113, 2000.
Scholz, C., et al.,Cooperation of Enzymatic and Chaperon Functions of Trigger Factor in the Catalysis of Protein Folding, The EMBO Journal, vol. 16, No. 1, pp. 54-58, 1997.
Spreng S. and Gentschev I., “Construction of Chromosomally Encoded Secreted Hemolysin Fusion Proteins By Use of Mini-TnhlyAsTransposon,”FEMS Microbiology Letters(1998) 165:187-192.
Schein C., “Production of Soluble Recombinant Proteins in Bacteria,”Biotechnology Nature(Nov. 1989) 7(11): 1141-1149.
Nishihara K. et al., “Overexpression of Trigger Factor Prevents Aggregation of Recombinant Proteins inEscherichia coli,” Applied and Enviromental Microbiology (Mar. 2000) 66(3):884-889.
Arié, J.P., et al.,Molecular Microbiology, 39(1):199-210 (2001).

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