Fused somatotropin epitopic peptides that potentiate growth horm

Details Fused somatotropin epitopic peptides that potentiate growth horm Fused somatotropin epitopic peptides that potentiate growth horm

1997-04-30

1999-03-30

Ulm, John

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

530324, 530350, 530399, 435 697, 536 234, 930120, C07K 1400, C07K 1461, C12N 1518

Patent

active

058891447

ABSTRACT:
This invention relates to composite somatotropin peptides comprising somatotropin epitopic amino acid sequences, and fusion proteins thereof, useful in potentiating growth hormone activity. Also disclosed are vectors and host cells useful in the recombinant production of such molecules. Vaccines containing the composite somatotropin peptides and fusion proteins of the present invention, and methods of using the same, are disclosed.

REFERENCES:
patent: 4425437 (1984-01-01), Riggs
patent: 4578355 (1986-03-01), Rosenberg
patent: 4803072 (1989-02-01), Dalton et al.
patent: 5210180 (1993-05-01), Wang et al.
patent: 5338836 (1994-08-01), Wang et al.
patent: 5506107 (1996-04-01), Cunningham et al.
patent: 5547669 (1996-08-01), Rogers et al.
Cunningham and Wells, 1989, High-resolution epitope mapping of hGH-receptor interactions by alanine-scanning mutagenesis, Science 244:1081-1085.
Germino and Bastia, 1984, Rapid purification of a clone gene product by genetic fusion and site-specific proteolysis, Proc. Natl. Acad. Sci. USA, 81: 4692-4696.
Shen, 1984, Multiple joined genes prevent product degradation in Escherichia coli, Proc. Natl. Acad. Sci. USA, 81: 4627-4631.
Aston et al., 1987, Enhancement of bovine growth hormone activity in vivo by monoclonal antibodies, Mol. Immun., 24:143-150.
Li et al., 1974, Human pituitary growth hormone: isolation and properties of two biologically active fragments from plasmin digests, Proc. Natl. Acad. Sci. USA 71:1197-1201.
Aston et al., 1983, Antigenic, receptor-binding and mitogenic activity of proteolytic fragments of human growth hormone, EMBO, 2:493-497.
Seeburg et al, 1983, Efficient bacterial expression of bovine and porcine growth hormones, DNA 2:37-45.
Young et al., 1983, Efficient bacterial expression of influenza virus NS1 nonstructural proteins in E. coli, Proc. Natl. Acad. Sci. USA 80:6105-6109.
Aston et al., 1991, Antigenic structure of a bovine growth hormone: location of a growth enhancing region, Mol. Immunol. 28:41-50.

Affiliated with

Also associated with

Rating

Fused somatotropin epitopic peptides that potentiate growth horm does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Fused somatotropin epitopic peptides that potentiate growth horm, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Fused somatotropin epitopic peptides that potentiate growth horm will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1216215