Fused heterocyclic derivative and use thereof

Details Fused heterocyclic derivative and use thereof Fused heterocyclic derivative and use thereof

2007-08-03

2011-10-25

Wilson, James O (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C544S236000

Reexamination Certificate

active

08044049

ABSTRACT:
The present invention provides a fused heterocyclic derivative having a potent kinase inhibitory activity and use thereof.A compound represented by the formula (I):wherein each symbol is as defined in the specification, except a particular compound, or a salt thereof, and a pharmaceutical agent containing the compound or a prodrug thereof, which is a kinase (VEGFR, VEGFR2, PDGFR, Raf) inhibitor, an angiogenesis inhibitor, an agent for the prophylaxis or treatment of cancer, a cancer growth inhibitor or a cancer metastasis suppressor.

REFERENCES:
patent: 7723336 (2010-05-01), Vaccaro et al.
patent: 2010/0216798 (2010-08-01), Nakai et al.
patent: 1 153 920 (2001-11-01), None
patent: 1 415 987 (2004-05-01), None
patent: 8-20584 (1996-01-01), None
patent: 89/01333 (1989-02-01), None
patent: 89/01478 (1989-02-01), None
patent: 98/35958 (1998-08-01), None
patent: 00/42012 (2000-07-01), None
patent: 00/43366 (2000-07-01), None
patent: 01/32651 (2001-05-01), None
patent: 01/60814 (2001-08-01), None
patent: 02/32872 (2002-04-01), None
patent: 2005/066177 (2005-07-01), None
patent: 2007/013673 (2007-02-01), None
patent: 2008/016131 (2007-02-01), None
patent: 2007/025090 (2007-03-01), None
patent: 2007/025540 (2007-03-01), None
patent: 2007/038314 (2007-04-01), None
Barlin, et al., Austral. J. Chem. (1996), 49(4), 443-449 [Barlin (III)].
Stanovnik, et al., Tetrahedron (1967), 23(1), 387-95.
Registry Compound, Oct. 2008.
Bullock, et al., “Structural Basis of Inhibitor Specificity of the Human Protooncogene Proviral Insertion Site in Moloney Murine Leukemia Virus (PIM-1) Kinase”, J. Med. Chem. 2005, 48, 7604-7614.
Mourad, et al., “Synthesis of Imidazo[1,2-b]pyridazines: Fenbendazole, Oxifenbendazole Analogs and Related Derivatives”, J. Heterocyclic Chem., 30, 1365-1372, Oct.-Nov. 1993.
Barlin, et al., “Imidazo[1,2-b]pyridazines. II 6-Alkylthio- and 6-Arylthio-3-methoxy- 2-phenylimidazo [1,2-b-]pyridazines” Aust. J. Chem., 1987, 40, 1491-7.
Barlin, et al., “Imidazo[1,2-b]pyridazlines IV Syntheses and Central Nervous System Activities of Some 3-Methoxy-6-phenoxy(substituted phenoxy and naphthylocy)-2-phenylimidazo[1,2-b]pyridazines”, Aust. J. Chem, 1988, 41, 1735-42.
Treb{hacek over (s)}e, et al., “A Direct Conversion of 5,6,7,8-Tetrahydro-2H-1-Benzo-Pyran-2,5-Diones into Substituted 1-Amion-5,6,7,8-Tetra-Hydroquinoline-2,5-Diones”, Heterocycles, vol. 59, No. 1, 129-136, 2003.
Treb{hacek over (s)}e, et al., “Transformation of 5-Oxo Substituted Fused Pyran-2-ones. LactamVersusHydrazone Formation”, Synthetic Communications, 27(15), 2637-2644, 1997.
Goli{hacek over (c)} Grdadolnik, et al., “Structural Investigation of 5-Hydrazono-5,6,7,8-tetrahydro-2H-1-benzopyran-2-ones and 5,6,7,8-Tetrahydroquinoline-2,5(1H)-diones”, J. Chem. Inf. Comput. Sci. 1997, 37, 489-494.
Ishikawa, et al., “Synthesis and Antibacterial Activity of 7 β-[2-(5-Amino-1,2,4-thiadiazol-3-y1)-2(Z)- alkoxyiminoacetamido]-3-[(E)-2-(1-alkylimidazo[1,2-b]pyridazinium-6-yl)thiovinyl]-3-cephem-4-carboxylates and Related Compounds”, The Journal of Antibiotics, 54(3), 257-277, Mar. 2001.
Matter. Alex, “Tumor angiogenesis as a therapeutic target”, DDT vol. 6, No. 19, Oct. 2001, pp. 1005-1024.
Ferrara, et al., “The Biology of Vascular Endothelial Growth Factor”, Endocrine Reviews, vol. 18, No. 1, Feb. 1997, pp. 4-25.
Folkamn, Judah, “Tumor Angiogenesis: Therapeutic Implications, The New England Journal of Medicine”, vol. 285, No. 21, Nov. 1971, pp. 1182-1186.

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