Fused azepine derivatives and their use as antidiuretic agents

Details Fused azepine derivatives and their use as antidiuretic agents Fused azepine derivatives and their use as antidiuretic agents

2007-02-13

2007-02-13

Coleman, Brenda (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C514S211100, C514S213010, C514S215000, C514S221000, C540S552000, C540S567000, C540S568000, C540S573000, C540S578000, C540S580000, C540S593000

Reexamination Certificate

active

10311301

ABSTRACT:
Compounds according to general formulae (1 and 2), wherein G1is an azepine derivative and G2is a group according to general formulae (9–11) are new. Compounds according to the invention are vasopressin V2receptor agonists. Pharmaceutical compositions of the compounds are useful as antidiuretic agents

REFERENCES:
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Ogawa et al. “Orally Active Nonpeptide Vasopressin V2Receptor Antagonists: A Novel Series of 1-[4-(Benzoylamino) benzoyl]-2,3,4,5-tetrahydro-1H-benzazepines and Related Componds,” J. Med. Chem., 39:3547-3555 (1996).

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