Fungal cell wall synthesis gene

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C435S254100, C435S007310, C435S320100, C435S069100, C514S002600

Reexamination Certificate

active

07999090

ABSTRACT:
The present invention provides isolated DNA encoding a GWT1 protein having activity to confer resistance of a fungus against a compound of formula Ia, and wherein a defect of a function of the GWT1 protein leads to a decrease in the amount of a glycosylphosphatidylinositol (GPI)-anchored protein in the cell wall of a fungus.

REFERENCES:
patent: 4013666 (1977-03-01), Lenz
patent: 5525716 (1996-06-01), Olsen et al.
patent: 5641627 (1997-06-01), Moehle
patent: 5648465 (1997-07-01), Margolis et al.
patent: 5962252 (1999-10-01), McFarland et al.
patent: 5969102 (1999-10-01), Bram et al.
patent: 6747137 (2004-06-01), Weinstock et al.
patent: 6833447 (2004-12-01), Goldman
patent: 7375204 (2008-05-01), Tsukahara et al.
patent: 2002/0072051 (2002-06-01), Bulawa et al.
patent: 2004/0029129 (2004-02-01), Wang et al.
patent: 2006/0172404 (2006-08-01), Hata et al.
patent: 2006/0234283 (2006-10-01), Tsukahara et al.
patent: 2006/0234349 (2006-10-01), Tsukahara et al.
patent: 2006/0240429 (2006-10-01), Tsukahara et al.
patent: 2006/0280725 (2006-12-01), Bode
patent: 2007/0287151 (2007-12-01), Linnarsson
patent: 2008/0261272 (2008-10-01), Tsukahara et al.
patent: 2009/0098636 (2009-04-01), Tsukahara et al.
patent: 2009/0325228 (2009-12-01), Tsukahara et al.
patent: WO 94/01567 (1993-07-01), None
patent: WO 94/01567 (1994-01-01), None
patent: WO 99/39197 (1999-08-01), None
patent: WO 00/01387 (2000-01-01), None
Mohuczy, D., et al., “Delivery of Antisense DNA by Vectors for Prolonged Effects in Vitro and in Vivo,”Methods in Enzymology, vol. 314, pp. 32-51 (2000).
Van Der Vaart, J. M., et al., “Identification of Three Mannoproteins in the Cell Wall ofSaccharomyces cetevisiae,” Journal of Bacteriology, Jun. 1995, pp. 3104-3110, vol. 177, No. 11, American Society for Microbiology.
Wikipedia (2007, updated) Homology (biology) http://en.wikipedia.org/wiki/Homology/˜(biology), p. 1.
Anderson, P., et al., “DNA Quality Control for Oligonucleotide Array CGH (aCGH) with the Agilent 2100 Bioanalyzer,” pp. 1-10 (2005).
Davila, J.C, et al.; “Cytotoxicity induced by papaverine hydrochloride in fungal cell systems”; 1990,Toxicology Letter, vol. 54, pp. 23-31.
Hamada, K., et al., “Screening for Glycosylphoshpatidylinsitol (GPI)-Dependent Cell Wall Proteins inSaccharomyces cerevisiae,” Molecular and General Genetics. Apr. 1998, pp. 53-59. vol. 258, No. 1-2. Springer-Verlag.
Ikezawa, H., et al., “Glycosylphosphatidylinositol (GPI)-anchored proteins,” 2002,Biol. Pharm, Bull., vol. 25(4), pp. 409-417.
Mamyrbekova. Z.A. et al.; “Synthesis, structure, and biological activity of paracyclophane derivatives”; 1995,Chemical Abstracts, vol. 123, p. 592.
Mamyrbekova, Z.A. et al.; 1994,Khim Pharm., vol. 28, No. 3, pp. 48-51.
Miosga, T. et al.; “S cerevisiaechromosome X reading frame ORF YJL091c”;GenBank Database; Aug. 11, 1997; Accession No. Z49366.
Miosga, T. et al.; “GPI-anchored wall transfer protein 1 (Inositol acyltransferase GWT1)”;GenBank Database; Accession No. P47026 (Feb. 1, 1996).
Miosga, et al., “Sequence Analysis of a 33-1 kb Fragment From the Left Arm ofSaccharmyces cerevisiaeChromosome X, Including Putative Proteins With Leucine Zippers, A Fungal Zn(II)2-Cys6Binuclear Cluster Domain and a Putative α2-SCB-α2 Binding Site”,Yeast, vol. 11: 681-689 (1995).
Mohuczy, D., et al., “Delivery of Antisense DNA by Vectors for Prolonged Effects in Vitro and in Vivo,”Methods in Enzymology, vol. 314, pp. 32-51 (1999).
Prostakov, N. S. et al.; 1980,Chemical Abstracts, vol. 93, No. 17, p. 660.
Seow, W.K. et al.; 1993,Chemical Abstracts, Vol. 119, No. 23, p. 32.
Seow, W.K: et al.; “Inhibitory effects of bisbenzylisoquinolines on synthesis of the inflammatory cytokines interleukin-1 and tumor necrosis factor-alpha”; 1993,Mediators of Inflammation, vol. 2, pp. 199-203.
Shiotani, Shunsaku et al.; “Witting-Horner Reaction of a Phosphonate of Reissert Analogues of Furo”; 1997,J. Heterocyclic Chemistry, vol. 34, No. 1, pp. 129-141.
Skrzypek, M., et al., Suppressor Gene Analysis Reveals an Essential Role for Sphingolipids in Transport of Glycosylphosphatidylinositol-Anchored Proteins inSaccharomyces cerevistae, Journal of Bacteriology, vol. 179(5), pp. 1513-1520 (Mar. 1997).
Smirnov, L.D. et al.; 1975,Chemical Abstracts, vol, 82, No. 3, p. 484.
Smirnov, L.D. et al.: 1974,Khim Geterotsikl, vol, 8, pp. 1094-1095.
Sütterlin , C., et al., “Saccharomyces cerevisiaeCGI10, the functional homologue of humanPIG-B, is required for glycosylphosphatidylinositol-anchor synthesis,”Biochem. J., vol. 332, pp. 153-159 (1998).
Tsai, I.L. et al.; 1989,Chemical Abstracts, vol. 111, No. 5, p. 342.
Tsai, I.L. et al : “Screening of Isoquinoline Alkaloids and their Derivatives for Antibacterial and Antifungal Activities”; 1989,Kalhsiung J. Med. Sci., vol. 5, pp. 132-145.
Tsukahara. K., et al., “Medicinal Genetics Approach Towards Identifying the Molecular Target of a Novel Inhibitor of Fungal Cell Wall Assembly,”Molecular Microbiology, May 2003, pp, 1029-1042, vol, 48, No. 4, Blackwell Publishing Ltd.
Umemura, M., et al., “GWT1Gene is Required for Inositol Acylation of Glycosylphosphatidylinositol Anchors in Yeast,”Journal of Biological Chemistry, Jun. 2003, pp. 23639-23647. vol. 278, No. 26, The American Society for Biochemistry and Molecular Biology, Inc., U.S.A.
Van Der Vaart, J. M., et al., “Identification of Three Mannoproteins in the Cell Wall ofSaccharomyces cerevisise,” Journal of Bacteriology, Jun. 1995, pp. 3104-3110, vol. 117, No. 11, American Society for Microbiology.
White, et al., “Clinical, cellular, and molecular factors that contribute to antifungal drug resistance,”Clin. Microbiol. Rev., 1998, vol. 11, pp. 382-402, Review.
Attachment 1 (2005) Sequence alignment between nucleotide sequences of instant SEQ ID No. 3 and SEQ ID No. 998 of US Pat. No. 6,747,137, pp. 1-4.
GenBank No. CAB59690, Oct. 1999, 3 pages.
Database EMBL Online; Accession No. AL132675; Created on Oct. 27, 1999; Description: S.pombe Chromosome I Cosmid c144, 9 pages.
Wikipidia (2007, updated ) Homology (biology) http://en.wikipedia.org/wikilHomology/˜(biology), p. 1.
Wiktionary (2007, updated) “transformant”, http://en.wiktionary.org/wiki/transformant, p. 1.
Miosga, et al.; GenBank Accession No. CAA89384 http://www.ncbi.nim.nih.gov/protein/1008262.
Futerman, A., “Inhibition of sphingolipid synthesis: effects on glycosphingolipid-GPI-anchored protein microdomains,”Trends Cell Biol., vol. 5(10), pp. 377-380 (Oct. 1995).
Zhang, C.-T., et al., “An analysis of base frequencies in the anti-sense strands corresponding to the 180 human protein coding sequences,”Amino Acids, vol. 10, pp. 253-262 (1996).
Prostakov, N.S. et al.; 1980,Khim Gelerotsikl Soedin, vol. 5, pp. 673-676.
Miosga, et al.; GenBank Accession No. CAA89384 http://www.ncbi.nlm.nih.gov/protein/1008262, (Aug. 1997).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Fungal cell wall synthesis gene does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Fungal cell wall synthesis gene, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Fungal cell wall synthesis gene will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2636715

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.