Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,...
Reexamination Certificate
2006-09-05
2006-09-05
Ungar, Susan (Department: 1642)
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
C435S004000, C435S007100, C424S138100, C424S139100, C424S152100
Reexamination Certificate
active
07101548
ABSTRACT:
The methods of the present invention demonstrate that adrenomedullin (AM) is expressed in human cancer cell lines of diverse origin and functions as a universal autocrine growth factor driving neoplastic proliferation. The present invention provides for AM peptides and AM antibodies useful in therapeutic, pharmacologic and physiologic compositions. The present invention additionally provides for methods of diagnosis, treatment and prevention of disease utilizing compositions comprising the AM peptides and antibodies of the present invention. The methods of the present invention also provide for experimental models for use in identifying the role of AM in pancreatic physiology. The methods pertaining to rat isolated islets have shown that AM inhibits insulin secretion in a dose-dependent manner. The monoclonal antibody MoAb-G6, which neutralizes AM bioactivity, was shown by the methods of the present invention to increase insulin release fivefold, an effect that was reversed by the addition of synthetic AM.
REFERENCES:
patent: 0 622 458 (1994-11-01), None
patent: WO 93/17715 (1993-09-01), None
patent: WO 94/25482 (1994-11-01), None
Kimmel et al (J. Neurosurg, 1987, 66:1611-171).
Hird et al (Genes and Cancer, Carney et al., Ed., John WIley and Sons, LTS, 1990, pp. (83-189)
Feshney (Culture of Animal Cellw, A Manual of Basic Technique, Alan R. Liss, Inc., 1983, NY, p. 4).
Dermer (Bio/Technoloy, 1994, 12:20).
Drexler et al (Leukemia and LYmphoma, 1993, 9:1-25).
Zellner et al (Clin. Can. Res., 1998, 4:1797-1802).
Embleton et al (Immunol. Ser., 1984, 23;181-207).
Hsu (in Tissue Culture Methods and Applications, Kruse and Patterson, Eds., 1973, Academic Press, NY, see abstract, p. 764).
Slamon et al (Cancer Cells, 1989, 7:371-384).
Gura (Science, 1997, 278:1041-1042).
Curti (Crit. Rev. in Oncology/Hematology, 1993, 14:29-39).
Hartwell et al (Science, 1997, 278: 1064-1067).
Schlom (in Molecular Foundations of Oncology, 1991, Broder Ed., Williams and Williams, Baltimore, pp. 95-134).
Cuttitta et al., “Bombesin-like peptides can function as autocrine growth factors in human small-cell lung cancer,”Nature316(6031):823-826, 1985.
Ishikawa et al., “Adrenomedullin Antagonist Suppresswesin VivoGrowth of Human Pancreatic Cancer Cells in SCID Mice by Suppressing Angiogensis,”Oncogene22:1238-1242, 2003.
Martinez et al., “Is Adrenomedullin a Causal Agent in Some Cases of Type 2 Diabetes?”Peptides20:1471-1478, 1999.
Martinez et al., “Regulation of INsulin Secretion and Blood Glucose Metabolism by Adrenmedullin,”Endocrinology137(6):2626-2632, 1996.
Ouafik et al., “Neutralization of Adrenomedullin INhibits the Growth of Human Glioblastoma Cell Linesin Vitroand Suppresses Tumor Xenograft Growthin Vivo,”American Journal of Pathology160(4):1279-1292, 2002.
Ruggeri et al., “CEP-7055: A Novel, Orally Active Pan Inhibitor of Vascular Endothelial Growth Factor Receptor Tyrosine Kinases with Potent Antiangiogenic Activity and Antitumor Efficacy in Preclinical Models,”Cancer Research63:5978-5991, 2003.
K. Kitamura et al., “Adrenomedullin: A novel hypotensive peptide isolated from human pheochromocytoma,” Biochem. Biophys. REs. COmmun., 192[2]:553-560, 1993.
S., Sugo et al., “Production and secretion of adrenomedullin from vascular smooth muscle cells: Augmented production by tumor necrosis factor-α.” Biochem. Biophys. Res. Commun., 203[1]:719-726, 1994.
H. Kanazawa et al., “Adrenomedullin, a newly discovered hypotensive peptide, is a potent bronchodilator,” Biochem. Biophys. Res. Commun., 205[1]:251-254, 1994.
T. Yamaguchi et al., “Effect of adrenomudillin on aldosterone secretion by dispersed rat adrenal zona glomerulosa cells,” Life. Sci., 56[6]:379-387, 1995.
S. Sugo et al., “Interleukin-1, tumor-necrosis-factor and lipopolysaccharides additiviely stimulates production of adrenomedullin in vascular smooth muscle cells.” Biochem. Biophys. Res. Commun., 207[1];25-32, 1995.
F. Satoh et al., “Adrenomedullin in human brain, adrenal-glands and tumor-tissues of pheochromocytoma, ganglioneuroblastoma and neuroblastoma.” J. Clin. Endocrinol. Metabol., 80[5]:1750-1752, 1995.
H. Kamoi et al., “Adrenomedullin inhibits the secretion of cytokine-induced neutrophil chemoattractant, a member of the interleukin-8 family, from rat alveolar macrophages.” Biochem. Biophys. Res. Commun., 211[3]:1031-1035, 1995.
E. Ahren et al., “Adrenomedullin is localized to the gut and stimulates insulin-secretion in the rat.” Diabetologia 38:108A, 1995 (Abstract).
H. Michibata et al., “Production and action of adrenomedullin (AM) in culture mesangial cells revealed by a specific monoclonal antibody to AM.” J. Amer. Soc. Nephrol., 6:741, 1995 (Abstract #1856).
S. Kobayashi et al., “Adrenomedullin stimulates the cell cycle progression and the expression of c-fos messenger RNA in vascular smooth muscle cells in primary culture.” Circulation, 92:I-694, 1995 (Abstract #3335).
A. Sato et al., “Adrenomedullin induces expression of c-fos and AP-1 activity in rat vascular smooth muscle cells and cardiomyocytes.” Biochem. Biophys. Res. Commun., 217[1]:211-216, 1995.
T. Iami et al., “Hormonal regulation of rat adrenomedullin gene in vasculature.” Endocrinology, 136[4]:1544-1548, 1995.
W.K. Samson et al., “A novel vasocative peptide, adrenomedullin inhibits pituitary adrenocorticotropin release.” Endocrinology, 136[5]:2349-2352, 1995.
M.J. Miller et al., “Expression of adrenomedullin mRNA in normal human tissues and cancer cell lines as expressed by RT-PCR and immunoblot,” Proc. Amer. Assoc. Canc. Res., 36;261, 1995(Abstract #1554).
A. Martinez et al., “Adrenomedullin, a new hypotensive peptide, is expressed in normal lung and in primary tumors.” Proc. Amer. Assoc. Canc. Res., 36:265, 1995 (Abstract #1580).
A. Martinez et al., “Epxression of adrenomedullin in normal human lung and in primary tumors.” Endocrinology 136[9]:4099-4105, 1995.
G.D. Parkes et al., “ACTH-suppressive and vasodilator actions of adrenmedullin in conscious sheep.” Journal of Neuroendocrinology (J. Neuroendo.), 7:923-929, 1995.
Cuttitta Frank
Gray Karen
Hook William
Macri Charles
Martinez Alfredo
Klarquist & Sparkman, LLP
The United States of America as represented by the Department of
Ungar Susan
LandOfFree
Functional role of adrenomedullin (AM) and the gene-related... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Functional role of adrenomedullin (AM) and the gene-related..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Functional role of adrenomedullin (AM) and the gene-related... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3586921