Fully human anti-epidermal growth factor receptor antibodies

Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,...

Reexamination Certificate

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C424S141100, C424S142100, C424S143100, C424S178100, C424S183100, C435S007100, C435S007200, C435S007300, C530S387100, C530S388100, C530S388150, C530S388220, C530S391300, C530S391700

Reexamination Certificate

active

08071093

ABSTRACT:
Disclosed are fully human anti-epidermal growth factor receptor (EGFR) antibodies, fragments thereof, and nucleic acid sequences encoding for the same. Further disclosed are methods of making and using the antibodies.

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Goldstein, N.I. et al., Biological Efficacy of a Chimeric Antibody to the Epidermal Growth Factor Receptor in a Human Tumor Xenograft Model, Clin Cancer Res. 1995; 1(11): 1311-1318.
Vaughan, T.J. et al., Human Antibodies with Sub-nanomolar Affinities Isolated from a Large Non-immunized Phage Display Library, Nature Biotechnology 1996;14: 309-314.

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